Sex differences in depressive response during monoamine depletions in remitted depressive subjects

Francisco Moreno, Cynthia A. McGahuey, Marlene P. Freeman, Pedro L. Delgado

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective: Although sex differences in the prevalence of depression are well known, the effects of sex on the underlying mechanisms of illness and on antidepressant action remain less clear. Tryptophan depletion and catecholamine depletion (via α-methylparatyrosine [AMPT] administration) are broadly utilized methods for studying the effects of the safe and transient reduction of serotonin and catecholamine neurotransmission, respectively. The present study assessed the effects of sex on the mood response during acute monoamine depletion. Method: Data on Hamilton Rating Scale for Depression (HAM-D) scores during depletion tests were analyzed retrospectively in 59 subjects (41 women, 18 men) who underwent tryptophan depletion and 39 subjects (25 women, 14 men) who underwent catecholamine depletion. All subjects were in remission from a DSM-IV-defined major depressive episode. Data reviewed included subjects enrolled between November 1993 and November 1997. Results: Significant increases in HAM-D scores were observed in response to both depletion procedures, with a similar magnitude of change. Analysis of variance with repeated measures of HAM-D scores revealed a significant main effect of time for tryptophan depletion (F = 7.31, df = 3, p < .01) and for catecholamine depletion (F = 9.61, df = 4, p < .01). Time-by-sex interaction was significant for tryptophan depletion (F = 4.04, df = 3, p = .01), but not for catecholamine depletion (F = 0.75, df = 4, p = .57). Depressive symptoms were significantly greater in women during tryptophan depletion (t test p < .01), while no significant sex differences were found during catecholamine depletion. Conclusions: These findings suggest that the effect of sex in depressive vulnerability may be related to differential sex effects in monoaminergic function.

Original languageEnglish (US)
Pages (from-to)1618-1623
Number of pages6
JournalJournal of Clinical Psychiatry
Volume67
Issue number10
StatePublished - Oct 2006

Fingerprint

Sex Characteristics
Catecholamines
Tryptophan
Depression
Synaptic Transmission
Diagnostic and Statistical Manual of Mental Disorders
Antidepressive Agents
Serotonin
Analysis of Variance

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Sex differences in depressive response during monoamine depletions in remitted depressive subjects. / Moreno, Francisco; McGahuey, Cynthia A.; Freeman, Marlene P.; Delgado, Pedro L.

In: Journal of Clinical Psychiatry, Vol. 67, No. 10, 10.2006, p. 1618-1623.

Research output: Contribution to journalArticle

Moreno, Francisco ; McGahuey, Cynthia A. ; Freeman, Marlene P. ; Delgado, Pedro L. / Sex differences in depressive response during monoamine depletions in remitted depressive subjects. In: Journal of Clinical Psychiatry. 2006 ; Vol. 67, No. 10. pp. 1618-1623.
@article{75e16e1748ee4d009aad5a3a29eb2627,
title = "Sex differences in depressive response during monoamine depletions in remitted depressive subjects",
abstract = "Objective: Although sex differences in the prevalence of depression are well known, the effects of sex on the underlying mechanisms of illness and on antidepressant action remain less clear. Tryptophan depletion and catecholamine depletion (via α-methylparatyrosine [AMPT] administration) are broadly utilized methods for studying the effects of the safe and transient reduction of serotonin and catecholamine neurotransmission, respectively. The present study assessed the effects of sex on the mood response during acute monoamine depletion. Method: Data on Hamilton Rating Scale for Depression (HAM-D) scores during depletion tests were analyzed retrospectively in 59 subjects (41 women, 18 men) who underwent tryptophan depletion and 39 subjects (25 women, 14 men) who underwent catecholamine depletion. All subjects were in remission from a DSM-IV-defined major depressive episode. Data reviewed included subjects enrolled between November 1993 and November 1997. Results: Significant increases in HAM-D scores were observed in response to both depletion procedures, with a similar magnitude of change. Analysis of variance with repeated measures of HAM-D scores revealed a significant main effect of time for tryptophan depletion (F = 7.31, df = 3, p < .01) and for catecholamine depletion (F = 9.61, df = 4, p < .01). Time-by-sex interaction was significant for tryptophan depletion (F = 4.04, df = 3, p = .01), but not for catecholamine depletion (F = 0.75, df = 4, p = .57). Depressive symptoms were significantly greater in women during tryptophan depletion (t test p < .01), while no significant sex differences were found during catecholamine depletion. Conclusions: These findings suggest that the effect of sex in depressive vulnerability may be related to differential sex effects in monoaminergic function.",
author = "Francisco Moreno and McGahuey, {Cynthia A.} and Freeman, {Marlene P.} and Delgado, {Pedro L.}",
year = "2006",
month = "10",
language = "English (US)",
volume = "67",
pages = "1618--1623",
journal = "Journal of Clinical Psychiatry",
issn = "0160-6689",
publisher = "Physicians Postgraduate Press Inc.",
number = "10",

}

TY - JOUR

T1 - Sex differences in depressive response during monoamine depletions in remitted depressive subjects

AU - Moreno, Francisco

AU - McGahuey, Cynthia A.

AU - Freeman, Marlene P.

AU - Delgado, Pedro L.

PY - 2006/10

Y1 - 2006/10

N2 - Objective: Although sex differences in the prevalence of depression are well known, the effects of sex on the underlying mechanisms of illness and on antidepressant action remain less clear. Tryptophan depletion and catecholamine depletion (via α-methylparatyrosine [AMPT] administration) are broadly utilized methods for studying the effects of the safe and transient reduction of serotonin and catecholamine neurotransmission, respectively. The present study assessed the effects of sex on the mood response during acute monoamine depletion. Method: Data on Hamilton Rating Scale for Depression (HAM-D) scores during depletion tests were analyzed retrospectively in 59 subjects (41 women, 18 men) who underwent tryptophan depletion and 39 subjects (25 women, 14 men) who underwent catecholamine depletion. All subjects were in remission from a DSM-IV-defined major depressive episode. Data reviewed included subjects enrolled between November 1993 and November 1997. Results: Significant increases in HAM-D scores were observed in response to both depletion procedures, with a similar magnitude of change. Analysis of variance with repeated measures of HAM-D scores revealed a significant main effect of time for tryptophan depletion (F = 7.31, df = 3, p < .01) and for catecholamine depletion (F = 9.61, df = 4, p < .01). Time-by-sex interaction was significant for tryptophan depletion (F = 4.04, df = 3, p = .01), but not for catecholamine depletion (F = 0.75, df = 4, p = .57). Depressive symptoms were significantly greater in women during tryptophan depletion (t test p < .01), while no significant sex differences were found during catecholamine depletion. Conclusions: These findings suggest that the effect of sex in depressive vulnerability may be related to differential sex effects in monoaminergic function.

AB - Objective: Although sex differences in the prevalence of depression are well known, the effects of sex on the underlying mechanisms of illness and on antidepressant action remain less clear. Tryptophan depletion and catecholamine depletion (via α-methylparatyrosine [AMPT] administration) are broadly utilized methods for studying the effects of the safe and transient reduction of serotonin and catecholamine neurotransmission, respectively. The present study assessed the effects of sex on the mood response during acute monoamine depletion. Method: Data on Hamilton Rating Scale for Depression (HAM-D) scores during depletion tests were analyzed retrospectively in 59 subjects (41 women, 18 men) who underwent tryptophan depletion and 39 subjects (25 women, 14 men) who underwent catecholamine depletion. All subjects were in remission from a DSM-IV-defined major depressive episode. Data reviewed included subjects enrolled between November 1993 and November 1997. Results: Significant increases in HAM-D scores were observed in response to both depletion procedures, with a similar magnitude of change. Analysis of variance with repeated measures of HAM-D scores revealed a significant main effect of time for tryptophan depletion (F = 7.31, df = 3, p < .01) and for catecholamine depletion (F = 9.61, df = 4, p < .01). Time-by-sex interaction was significant for tryptophan depletion (F = 4.04, df = 3, p = .01), but not for catecholamine depletion (F = 0.75, df = 4, p = .57). Depressive symptoms were significantly greater in women during tryptophan depletion (t test p < .01), while no significant sex differences were found during catecholamine depletion. Conclusions: These findings suggest that the effect of sex in depressive vulnerability may be related to differential sex effects in monoaminergic function.

UR - http://www.scopus.com/inward/record.url?scp=33751225355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751225355&partnerID=8YFLogxK

M3 - Article

C2 - 17107256

AN - SCOPUS:33751225355

VL - 67

SP - 1618

EP - 1623

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

SN - 0160-6689

IS - 10

ER -