Sex in microbial pathogens

Harris Bernstein, Carol Bernstein, Richard E. Michod

Research output: Research - peer-reviewReview article

Abstract

We review the sexual processes common in pathogenic microorganisms and assess the primary adaptive benefit of such processes. The pathogenic microorganisms considered include bacteria, microbial eukaryotes, and viruses. The sexual processes include bacterial transformation, eukaryotic meiotic sex and virus multiplicity reactivation. Recent evidence shows that sexual processes are common in microbial pathogens. A major general challenge to pathogen survival and infectivity is the need to overcome the hostile defenses of their target host. These defenses characteristically involve production of stresses, including oxidative stress, that can damage the pathogen's genome. Pathogens appear generally to possess enzyme systems that are central to sex and are also associated with a particular type of genomic repair process, recombinational repair. For some pathogens, it has been directly demonstrated that infectivity and virulence depend on sex. The evidence reviewed here supports the conclusion that the primary benefit of sex in pathogens is the repair of genomic damages that would otherwise be deleterious or lethal. This conclusion is in agreement with similar conclusions derived from non-pathogenic model species of bacteria, microbial eukaryotes and viruses. In several pathogenic species it has been shown that the two partner genomes that engage in sex are most often clonally related or closely related genetically. Thus, in pathogenic species, sexual interactions likely generate little or no genetic variation among progeny. However, infrequent outcrossing can occur in these sexual species and this may have important long term consequences.

LanguageEnglish (US)
Pages8-25
Number of pages18
JournalInfection, Genetics and Evolution
Volume57
DOIs
StatePublished - Jan 1 2018

Fingerprint

pathogens
gender
pathogen
viruses
Viruses
repair
virus
eukaryotic cells
pathogenicity
microorganisms
genomics
genome
bacteria
Eukaryota
Genome
Bacteria
infectivity
eukaryote
microorganism
damage

Keywords

  • Bacterial transformation
  • DNA damage
  • Inbreeding
  • Meiosis
  • Microbial pathogen
  • Multiplicity reactivation
  • Recombination
  • Sex

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Sex in microbial pathogens. / Bernstein, Harris; Bernstein, Carol; Michod, Richard E.

In: Infection, Genetics and Evolution, Vol. 57, 01.01.2018, p. 8-25.

Research output: Research - peer-reviewReview article

Bernstein H, Bernstein C, Michod RE. Sex in microbial pathogens. Infection, Genetics and Evolution. 2018 Jan 1;57:8-25. Available from, DOI: 10.1016/j.meegid.2017.10.024
Bernstein, Harris ; Bernstein, Carol ; Michod, Richard E./ Sex in microbial pathogens. In: Infection, Genetics and Evolution. 2018 ; Vol. 57. pp. 8-25
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