Sex-related developmental differences in the lateralized activation of the prefrontal cortex and amygdala during perception of facial affect

William Killgore, Deborah A. Yurgelun-Todd

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The lateralization of cognitive abilities is influenced by a number of factors, including handedness, sex, and developmental maturation. To date, a small number of studies have examined sex differences in the lateralization of cognitive and affective functions, and in only few of these have the developmental trajectories of these lateralized differences been mapped from childhood through early adulthood. In the present study, a cross-sectional design was used with healthy children (n = 7), adolescents (n = 12), and adults (n =10) who underwent functional magnetic resonance imaging (fMRI) during a task that required perceiving fearful faces. Males and females differed in the asymmetry of activation of the amygdala and prefrontal cortex across the three age groups. For males, activation within the dorsolateral prefrontal cortex was bilateral in children, right lateralized in adolescents, and bilateral in adults, whereas females showed a monotonic relationship with age, with older females showing more bilateral activation than younger ones. In contrast, amygdala activation was similar for both sexes, with bilateral activation in children, right-lateralized activation in adolescents, and bilateral activation in adults. These results suggest that males and females show different patterns of lateralized cortical and subcortical brain activation across the period of development from childhood through early adulthood.

Original languageEnglish (US)
Pages (from-to)371-391
Number of pages21
JournalPerceptual and Motor Skills
Volume99
Issue number2
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Amygdala
Prefrontal Cortex
Sexual Maturation
Functional Laterality
Aptitude
Sex Characteristics
Cognition
Age Groups
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • Psychology(all)
  • Experimental and Cognitive Psychology

Cite this

Sex-related developmental differences in the lateralized activation of the prefrontal cortex and amygdala during perception of facial affect. / Killgore, William; Yurgelun-Todd, Deborah A.

In: Perceptual and Motor Skills, Vol. 99, No. 2, 10.2004, p. 371-391.

Research output: Contribution to journalArticle

@article{439f81d845cb4f218bd43167c5a0b744,
title = "Sex-related developmental differences in the lateralized activation of the prefrontal cortex and amygdala during perception of facial affect",
abstract = "The lateralization of cognitive abilities is influenced by a number of factors, including handedness, sex, and developmental maturation. To date, a small number of studies have examined sex differences in the lateralization of cognitive and affective functions, and in only few of these have the developmental trajectories of these lateralized differences been mapped from childhood through early adulthood. In the present study, a cross-sectional design was used with healthy children (n = 7), adolescents (n = 12), and adults (n =10) who underwent functional magnetic resonance imaging (fMRI) during a task that required perceiving fearful faces. Males and females differed in the asymmetry of activation of the amygdala and prefrontal cortex across the three age groups. For males, activation within the dorsolateral prefrontal cortex was bilateral in children, right lateralized in adolescents, and bilateral in adults, whereas females showed a monotonic relationship with age, with older females showing more bilateral activation than younger ones. In contrast, amygdala activation was similar for both sexes, with bilateral activation in children, right-lateralized activation in adolescents, and bilateral activation in adults. These results suggest that males and females show different patterns of lateralized cortical and subcortical brain activation across the period of development from childhood through early adulthood.",
author = "William Killgore and Yurgelun-Todd, {Deborah A.}",
year = "2004",
month = "10",
language = "English (US)",
volume = "99",
pages = "371--391",
journal = "Perceptual and Motor Skills",
issn = "0031-5125",
publisher = "Ammons Scientific Ltd",
number = "2",

}

TY - JOUR

T1 - Sex-related developmental differences in the lateralized activation of the prefrontal cortex and amygdala during perception of facial affect

AU - Killgore, William

AU - Yurgelun-Todd, Deborah A.

PY - 2004/10

Y1 - 2004/10

N2 - The lateralization of cognitive abilities is influenced by a number of factors, including handedness, sex, and developmental maturation. To date, a small number of studies have examined sex differences in the lateralization of cognitive and affective functions, and in only few of these have the developmental trajectories of these lateralized differences been mapped from childhood through early adulthood. In the present study, a cross-sectional design was used with healthy children (n = 7), adolescents (n = 12), and adults (n =10) who underwent functional magnetic resonance imaging (fMRI) during a task that required perceiving fearful faces. Males and females differed in the asymmetry of activation of the amygdala and prefrontal cortex across the three age groups. For males, activation within the dorsolateral prefrontal cortex was bilateral in children, right lateralized in adolescents, and bilateral in adults, whereas females showed a monotonic relationship with age, with older females showing more bilateral activation than younger ones. In contrast, amygdala activation was similar for both sexes, with bilateral activation in children, right-lateralized activation in adolescents, and bilateral activation in adults. These results suggest that males and females show different patterns of lateralized cortical and subcortical brain activation across the period of development from childhood through early adulthood.

AB - The lateralization of cognitive abilities is influenced by a number of factors, including handedness, sex, and developmental maturation. To date, a small number of studies have examined sex differences in the lateralization of cognitive and affective functions, and in only few of these have the developmental trajectories of these lateralized differences been mapped from childhood through early adulthood. In the present study, a cross-sectional design was used with healthy children (n = 7), adolescents (n = 12), and adults (n =10) who underwent functional magnetic resonance imaging (fMRI) during a task that required perceiving fearful faces. Males and females differed in the asymmetry of activation of the amygdala and prefrontal cortex across the three age groups. For males, activation within the dorsolateral prefrontal cortex was bilateral in children, right lateralized in adolescents, and bilateral in adults, whereas females showed a monotonic relationship with age, with older females showing more bilateral activation than younger ones. In contrast, amygdala activation was similar for both sexes, with bilateral activation in children, right-lateralized activation in adolescents, and bilateral activation in adults. These results suggest that males and females show different patterns of lateralized cortical and subcortical brain activation across the period of development from childhood through early adulthood.

UR - http://www.scopus.com/inward/record.url?scp=10244237785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10244237785&partnerID=8YFLogxK

M3 - Article

C2 - 15560325

AN - SCOPUS:10244237785

VL - 99

SP - 371

EP - 391

JO - Perceptual and Motor Skills

JF - Perceptual and Motor Skills

SN - 0031-5125

IS - 2

ER -