Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats

Steve C. Danzer, Robin O. Price, Nathaniel T. McMullen, Naomi E. Rance

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Human menopause is associated with hypertrophy and increased gene expression of neurokinin (NKB) neurons in the infundibular (arcuate) nucleus of the hypothalamus. We have hypothesized that these changes are secondary to gonadal failure. In the present study, we determined that orchidectomy resulted in an increase in the mean profile area and the number of neurons expressing NKB mRNA in the rat arcuate nucleus. No changes were seen when orchidectomy was combined with testosterone or estradiol replacement. These findings support our hypothesis and demonstrate that gonadal steroids modulate NKB neurons in the arcuate nucleus of adult male rats.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalMolecular Brain Research
Volume66
Issue number1-2
DOIs
StatePublished - Mar 20 1999

Keywords

  • Estrogen
  • Hypothalamus
  • Menopause
  • Reproduction
  • Testosterone

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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