Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model

Kelli M. Sas, Jiahe Lin, Thekkelnaycke M. Rajendiran, Tanu Soni, Viji Nair, Lucy M. Hinder, Hosagrahar V. Jagadish, Thomas W. Gardner, Steven F. Abcouwer, Frank C. Brosius, Eva L. Feldman, Matthias Kretzler, George Michailidis, Subramaniam Pennathur

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Lipids are ubiquitous metabolites with diverse functions; abnormalities in lipid metabolism appear to be related to complications from multiple diseases, including type 2 diabetes. Through technological advances, the entire lipidome has been characterized and researchers now need computational approaches to better understand lipid network perturbations in different diseases. Using a mouse model of type 2 diabetes with microvascular complications, we examined lipid levels in plasma and in renal, neural, and retinal tissues to identify shared and distinct lipid abnormalities. We used correlation analysis to construct interaction networks in each tissue, to associate changes in lipids with changes in enzymes of lipid metabolism, and to identify overlap of coregulated lipid subclasses between plasma and each tissue to define subclasses of plasma lipids to use as surrogates of tissue lipid metabolism. Lipid metabolism alterations were mostly tissue specific in the kidney, nerve, and retina; no lipid changes correlated between the plasma and all three tissue types. However, alterations in diacylglycerol and in lipids containing arachidonic acid, an inflammatory mediator, were shared among the tissue types, and the highly saturated cholesterol esters were similarly coregulated between plasma and each tissue type in the diabetic mouse. Our results identified several patterns of altered lipid metabolism that May help to identify pathogenic alterations in different tissues and could be used as biomarkers in future research into diabetic microvascular tissue damage.

Original languageEnglish (US)
Pages (from-to)173-183
Number of pages11
JournalJournal of Lipid Research
Issue number2
StatePublished - 2018
Externally publishedYes


  • Eye
  • Kidney
  • Mass spectrometry
  • Nerve
  • Supplementary key words diabetes
  • Systems biology

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology


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