Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay

Lorenzo Valerio, Filippo Consolo, Danny Bluestein, Phat Tran, Marvin J Slepian, Alberto Redaelli, Federico Pappalardo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

Left ventricular assist devices (LVADs) have emerged as vital life-saving therapeutic systems for patients with advanced and end-stage heart failure (HF). Despite their efficacy, VAD systems remain limited by post-implantation thrombotic complications. Shear-mediated platelet activation is the major driver of such complications in these devices.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1255-1258
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
StatePublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

Fingerprint

Left ventricular assist devices
Heart-Assist Devices
Platelet Activation
Platelets
Ion implantation
Assays
Blood Platelets
Heart Failure
Chemical activation
Equipment and Supplies
Therapeutics

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Valerio, L., Consolo, F., Bluestein, D., Tran, P., Slepian, M. J., Redaelli, A., & Pappalardo, F. (2015). Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 1255-1258). [7318595] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7318595

Shear-mediated platelet activation in patients implanted with continuous flow LVADs : A preliminary study utilizing the platelet activity state (PAS) assay. / Valerio, Lorenzo; Consolo, Filippo; Bluestein, Danny; Tran, Phat; Slepian, Marvin J; Redaelli, Alberto; Pappalardo, Federico.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 1255-1258 7318595.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Valerio, L, Consolo, F, Bluestein, D, Tran, P, Slepian, MJ, Redaelli, A & Pappalardo, F 2015, Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7318595, Institute of Electrical and Electronics Engineers Inc., pp. 1255-1258, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7318595
Valerio L, Consolo F, Bluestein D, Tran P, Slepian MJ, Redaelli A et al. Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 1255-1258. 7318595 https://doi.org/10.1109/EMBC.2015.7318595
Valerio, Lorenzo ; Consolo, Filippo ; Bluestein, Danny ; Tran, Phat ; Slepian, Marvin J ; Redaelli, Alberto ; Pappalardo, Federico. / Shear-mediated platelet activation in patients implanted with continuous flow LVADs : A preliminary study utilizing the platelet activity state (PAS) assay. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 1255-1258
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