Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis

Marvin J. Slepian, Jawaad Sheriff, Marcus Hutchinson, Phat Tran, Naing Bajaj, Joe G.N. Garcia, S. Scott Saavedra, Danny Bluestein

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalJournal of Biomechanics
Volume50
DOIs
StatePublished - Jan 4 2017

Keywords

  • Fluid shear stress
  • Mechanical circulatory support
  • Mechanotransduction
  • Platelet activation
  • Thrombosis

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

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