Short- and long-term outcome for living pancreas donors

Jason F. Reynoso, Christine E. Gruessner, David E.R. Sutherland, Rainer W.G. Gruessner

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The advantages of living donor pancreas transplants for the recipient include good HLA matching, lower immunologic risk, less immunosuppression, lower risk of infection and of posttransplant malignancies, and shorter pancreas graft preservation time. In 2008, a total of 155 segmental pancreas transplants using living donors were reported to the International Pancreas Transplant Registry from six countries. Pancreas living donors need to undergo a thorough pretransplant endocrinologic workup in order to minimize the risk of metabolic complications. The pretransplant workup has evolved over time, after initial reports showed that up to 25% of living donors had elevated hemoglobin A1c levels after donation. Avoiding obesity after donation diminishes the risk of long-term metabolic complications. The risk of surgical complications for the donor (such as pancreatitis, pancreatic leak or fistula, pancreatic abscess, and pancreatic pseudocyst) is less than 5%. If both the donor and recipient operations are technically successful, the long-term graft survival rate is significantly higher for living (versus deceased) donor pancreas transplant recipients. Future long-term studies of metabolic function in living donors are warranted to determine whether living donor pancreas transplants can safely be applied more widely and whether living donors can be used for islet transplants.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume17
Issue number2
DOIs
StatePublished - Mar 1 2010

Keywords

  • Living donors
  • Metabolic complications
  • Metabolic workup
  • Pancreas transplantation

ASJC Scopus subject areas

  • Medicine(all)

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