Should Platelet-Rich Plasma or Stem Cell Therapy Be Used to Treat Osteoarthritis?

Hani Rashid, C. Kent Kwoh

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Osteoarthritis is the most common form of arthritis and unfortunately lacks disease-modifying treatments. This has led to a growing demand for more effective nonoperative treatment options. Platelet-rich plasma and mesenchymal stem cell therapy offer the potential to modify the natural course of knee osteoarthritis using cell-based technology. Because of the lack of high-quality evidence and the large degree of heterogeneity, in terms of study designs and measured outcomes, the use of platelet-rich plasma or mesenchymal stem cell therapy to treat knee osteoarthritis cannot be recommended at this time.

Original languageEnglish (US)
Pages (from-to)417-438
Number of pages22
JournalRheumatic Disease Clinics of North America
Volume45
Issue number3
DOIs
StatePublished - Aug 2019

Keywords

  • Knee osteoarthritis
  • Meta-analyses
  • Osteoarthritis
  • Platelet-rich plasma
  • Randomized controlled clinical trials
  • Regenerative medicine
  • Stem cells

ASJC Scopus subject areas

  • Rheumatology

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