Show me your license, please: Deregulation of centriole duplication mechanisms that promote amplification

Christopher W. Brownlee, Gregory C. Rogers

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Centrosomes are organelles involved in generating and organizing the interphase microtubule cytoskeleton, mitotic spindles and cilia. At the centrosome core are a pair of centrioles, structures that act as the duplicating elements of this organelle. Centrioles function to recruit and organize pericentriolar material which nucleates microtubules. While centrioles are relatively simple in construction, the mechanics of centriole biogenesis remain an important yet poorly understood process. More mysterious still are the regulatory mechanisms that oversee centriole assembly. The fidelity of centriole duplication is critical as defects in either the assembly or number of centrioles promote aneuploidy, primary microcephaly, birth defects, ciliopathies and tumorigenesis. In addition, some pathogens employ mechanisms to promote centriole overduplication to the detriment of the host cell. This review summarizes our current understanding of this important topic, highlighting the need for further study if new therapeutics are to be developed to treat diseases arising from defects of centrosome duplication.

Original languageEnglish (US)
Pages (from-to)1021-1034
Number of pages14
JournalCellular and Molecular Life Sciences
Volume70
Issue number6
DOIs
StatePublished - Mar 1 2013

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Keywords

  • Cell cycle
  • Centriole
  • Centrosome
  • Cytoskeleton
  • Microtubule
  • Mitosis

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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