Shrimp antimicrobial testing. II. toxicity testing and safety determination for twelve antimicrobials with penaeid shrimp larvae

Rodney R. Williams, Thomas A. Bell, Donald V. Lightner

Research output: Contribution to journalArticle

24 Scopus citations


The need for federally approved chemotherapeutants for use in domestic shrimp culture in the USA is acute. A summary of toxicity testing of 12 antimicrobials against penaeid shrimp larvae is presented. In addition, the toxicity data are examined in concert with previously reported data on minimum inhibitory concentrations to establish a therapeutic index (a measure of margin of safety) for each compound tested. The 11 prospective antimicrobials were compared with the reference compound, chloramphenicol. The antimicrobials tested were enrofloxacin, erythromycin, florfenicol, oxytetracycline, paromomycin, four experimental fluoroquinolines (PD124816, PD127391, PD131628, PD132133), Romet-30®, and Sarafin®. The top six compounds (in their relative order of safety, from the safest to the least safe) were PD127391, oxytetracycline, chloramphenicol, enrofloxacin, florfenicol, and Romet-30.

Original languageEnglish (US)
Pages (from-to)262-270
Number of pages9
JournalJournal of Aquatic Animal Health
Issue number4
StatePublished - Dec 1992


ASJC Scopus subject areas

  • Aquatic Science

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