Shrimp antimicrobial testing. II. toxicity testing and safety determination for twelve antimicrobials with penaeid shrimp larvae

Rodney R. Williams, Thomas A. Bell, Donald V Lightner

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The need for federally approved chemotherapeutants for use in domestic shrimp culture in the USA is acute. A summary of toxicity testing of 12 antimicrobials against penaeid shrimp larvae is presented. In addition, the toxicity data are examined in concert with previously reported data on minimum inhibitory concentrations to establish a therapeutic index (a measure of margin of safety) for each compound tested. The 11 prospective antimicrobials were compared with the reference compound, chloramphenicol. The antimicrobials tested were enrofloxacin, erythromycin, florfenicol, oxytetracycline, paromomycin, four experimental fluoroquinolines (PD124816, PD127391, PD131628, PD132133), Romet-30®, and Sarafin®. The top six compounds (in their relative order of safety, from the safest to the least safe) were PD127391, oxytetracycline, chloramphenicol, enrofloxacin, florfenicol, and Romet-30.

Original languageEnglish (US)
Pages (from-to)262-270
Number of pages9
JournalJournal of Aquatic Animal Health
Volume4
Issue number4
DOIs
StatePublished - 1992

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oxytetracycline
Penaeidae
toxicity testing
florfenicol
shrimp
anti-infective agents
enrofloxacin
chloramphenicol
safety
toxicity
shrimp culture
larva
larvae
margin of safety
testing
erythromycin
minimum inhibitory concentration
therapeutics
need
index

ASJC Scopus subject areas

  • Aquatic Science

Cite this

Shrimp antimicrobial testing. II. toxicity testing and safety determination for twelve antimicrobials with penaeid shrimp larvae. / Williams, Rodney R.; Bell, Thomas A.; Lightner, Donald V.

In: Journal of Aquatic Animal Health, Vol. 4, No. 4, 1992, p. 262-270.

Research output: Contribution to journalArticle

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