Sialic acid on leukemia cells: relation to morphology and tumor immunity

R. C. Reed, J. U. Gutterman, G. M. Mavligit, Evan M Hersh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Blast cells from 35 patients with adult acute leukemia and mononuclear cells from 10 normal donors were treated with neuraminidase and the amount of sialic acid released was measured. These values were correlated with the ability of the unmodified blasts to stimulate blastogenesis among autologous remission lymphocytes. Uniformly low amounts of sialic acid were released from leukemia lymphoblasts (10 patients). This was correlated with a consistently poor ability of these lymphoblasts to stimulate autologous lymphocytes. In contrast, a wider range of sialic acid levels were determined for leukemic myeloblasts (25 patients). Myeloblasts releasing excessively high amounts of sialic acid tended to stimulate autologous lymphocytes poorly compared to the vigorous stimulation evoked by myeloblasts releasing lower amounts. Similar studies of cell surface properties should facilitate the understanding of the immune response evoked by human tumor cells.

Original languageEnglish (US)
Pages (from-to)790-793
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume145
Issue number3
StatePublished - 1974
Externally publishedYes

Fingerprint

N-Acetylneuraminic Acid
Granulocyte Precursor Cells
Lymphocytes
Tumors
Immunity
Leukemia
Neoplasms
Surface Properties
Neuraminidase
Lymphocyte Activation
Surface properties
Cells
Tissue Donors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sialic acid on leukemia cells : relation to morphology and tumor immunity. / Reed, R. C.; Gutterman, J. U.; Mavligit, G. M.; Hersh, Evan M.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 145, No. 3, 1974, p. 790-793.

Research output: Contribution to journalArticle

@article{d23316e8b13644aea15092aa1af1263b,
title = "Sialic acid on leukemia cells: relation to morphology and tumor immunity",
abstract = "Blast cells from 35 patients with adult acute leukemia and mononuclear cells from 10 normal donors were treated with neuraminidase and the amount of sialic acid released was measured. These values were correlated with the ability of the unmodified blasts to stimulate blastogenesis among autologous remission lymphocytes. Uniformly low amounts of sialic acid were released from leukemia lymphoblasts (10 patients). This was correlated with a consistently poor ability of these lymphoblasts to stimulate autologous lymphocytes. In contrast, a wider range of sialic acid levels were determined for leukemic myeloblasts (25 patients). Myeloblasts releasing excessively high amounts of sialic acid tended to stimulate autologous lymphocytes poorly compared to the vigorous stimulation evoked by myeloblasts releasing lower amounts. Similar studies of cell surface properties should facilitate the understanding of the immune response evoked by human tumor cells.",
author = "Reed, {R. C.} and Gutterman, {J. U.} and Mavligit, {G. M.} and Hersh, {Evan M}",
year = "1974",
language = "English (US)",
volume = "145",
pages = "790--793",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "0037-9727",
publisher = "Society for Experimental Biology and Medicine",
number = "3",

}

TY - JOUR

T1 - Sialic acid on leukemia cells

T2 - relation to morphology and tumor immunity

AU - Reed, R. C.

AU - Gutterman, J. U.

AU - Mavligit, G. M.

AU - Hersh, Evan M

PY - 1974

Y1 - 1974

N2 - Blast cells from 35 patients with adult acute leukemia and mononuclear cells from 10 normal donors were treated with neuraminidase and the amount of sialic acid released was measured. These values were correlated with the ability of the unmodified blasts to stimulate blastogenesis among autologous remission lymphocytes. Uniformly low amounts of sialic acid were released from leukemia lymphoblasts (10 patients). This was correlated with a consistently poor ability of these lymphoblasts to stimulate autologous lymphocytes. In contrast, a wider range of sialic acid levels were determined for leukemic myeloblasts (25 patients). Myeloblasts releasing excessively high amounts of sialic acid tended to stimulate autologous lymphocytes poorly compared to the vigorous stimulation evoked by myeloblasts releasing lower amounts. Similar studies of cell surface properties should facilitate the understanding of the immune response evoked by human tumor cells.

AB - Blast cells from 35 patients with adult acute leukemia and mononuclear cells from 10 normal donors were treated with neuraminidase and the amount of sialic acid released was measured. These values were correlated with the ability of the unmodified blasts to stimulate blastogenesis among autologous remission lymphocytes. Uniformly low amounts of sialic acid were released from leukemia lymphoblasts (10 patients). This was correlated with a consistently poor ability of these lymphoblasts to stimulate autologous lymphocytes. In contrast, a wider range of sialic acid levels were determined for leukemic myeloblasts (25 patients). Myeloblasts releasing excessively high amounts of sialic acid tended to stimulate autologous lymphocytes poorly compared to the vigorous stimulation evoked by myeloblasts releasing lower amounts. Similar studies of cell surface properties should facilitate the understanding of the immune response evoked by human tumor cells.

UR - http://www.scopus.com/inward/record.url?scp=0015991914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015991914&partnerID=8YFLogxK

M3 - Article

C2 - 4522465

AN - SCOPUS:0015991914

VL - 145

SP - 790

EP - 793

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 0037-9727

IS - 3

ER -