Sickle cell disease is associated with iron mediated hypercoagulability

Nirmish Shah, Ian J. Welsby, Martha A. Fielder, Wayne K. Jacobsen, Vance G Nielsen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Sickle cell disease (SCD) is associated with a significant hypercoagulable state and several hemostatic anomalies have been identified in this disease state. Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly. We hypothesized that SCD patients would display hypercoagulable plasma coagulation kinetics and an iron enhancement of coagulation. After obtaining IRB approval, we assessed coagulation kinetics and iron enhancement with viscoelastic methods in archived, citrated plasma obtained from ambulatory or hospitalized SCD patients (n = 20). All SCD patients had plasmatic hypercoagulability, and 65 % were positive for iron enhancement of coagulation. In conclusion, continuing investigation correlating such viscoelastic data with clinical symptoms may provide insight into the role played by iron in the setting of SCD, including complications such as vaso-occlusive crisis.

Original languageEnglish (US)
Pages (from-to)182-185
Number of pages4
JournalJournal of Thrombosis and Thrombolysis
Volume40
Issue number2
DOIs
StatePublished - Aug 24 2015

Fingerprint

Thrombophilia
Sickle Cell Anemia
Iron
Research Ethics Committees
Hemostatics
Thrombin
Fibrinogen
Thrombosis

Keywords

  • Fibrinogen
  • Iron
  • Sickle cell disease
  • Thrombelastography

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Sickle cell disease is associated with iron mediated hypercoagulability. / Shah, Nirmish; Welsby, Ian J.; Fielder, Martha A.; Jacobsen, Wayne K.; Nielsen, Vance G.

In: Journal of Thrombosis and Thrombolysis, Vol. 40, No. 2, 24.08.2015, p. 182-185.

Research output: Contribution to journalArticle

Shah, Nirmish ; Welsby, Ian J. ; Fielder, Martha A. ; Jacobsen, Wayne K. ; Nielsen, Vance G. / Sickle cell disease is associated with iron mediated hypercoagulability. In: Journal of Thrombosis and Thrombolysis. 2015 ; Vol. 40, No. 2. pp. 182-185.
@article{e7b1395acfd04e9fbc6a3145f6962081,
title = "Sickle cell disease is associated with iron mediated hypercoagulability",
abstract = "Sickle cell disease (SCD) is associated with a significant hypercoagulable state and several hemostatic anomalies have been identified in this disease state. Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly. We hypothesized that SCD patients would display hypercoagulable plasma coagulation kinetics and an iron enhancement of coagulation. After obtaining IRB approval, we assessed coagulation kinetics and iron enhancement with viscoelastic methods in archived, citrated plasma obtained from ambulatory or hospitalized SCD patients (n = 20). All SCD patients had plasmatic hypercoagulability, and 65 {\%} were positive for iron enhancement of coagulation. In conclusion, continuing investigation correlating such viscoelastic data with clinical symptoms may provide insight into the role played by iron in the setting of SCD, including complications such as vaso-occlusive crisis.",
keywords = "Fibrinogen, Iron, Sickle cell disease, Thrombelastography",
author = "Nirmish Shah and Welsby, {Ian J.} and Fielder, {Martha A.} and Jacobsen, {Wayne K.} and Nielsen, {Vance G}",
year = "2015",
month = "8",
day = "24",
doi = "10.1007/s11239-015-1230-6",
language = "English (US)",
volume = "40",
pages = "182--185",
journal = "Journal of Thrombosis and Thrombolysis",
issn = "0929-5305",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - Sickle cell disease is associated with iron mediated hypercoagulability

AU - Shah, Nirmish

AU - Welsby, Ian J.

AU - Fielder, Martha A.

AU - Jacobsen, Wayne K.

AU - Nielsen, Vance G

PY - 2015/8/24

Y1 - 2015/8/24

N2 - Sickle cell disease (SCD) is associated with a significant hypercoagulable state and several hemostatic anomalies have been identified in this disease state. Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly. We hypothesized that SCD patients would display hypercoagulable plasma coagulation kinetics and an iron enhancement of coagulation. After obtaining IRB approval, we assessed coagulation kinetics and iron enhancement with viscoelastic methods in archived, citrated plasma obtained from ambulatory or hospitalized SCD patients (n = 20). All SCD patients had plasmatic hypercoagulability, and 65 % were positive for iron enhancement of coagulation. In conclusion, continuing investigation correlating such viscoelastic data with clinical symptoms may provide insight into the role played by iron in the setting of SCD, including complications such as vaso-occlusive crisis.

AB - Sickle cell disease (SCD) is associated with a significant hypercoagulable state and several hemostatic anomalies have been identified in this disease state. Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly. We hypothesized that SCD patients would display hypercoagulable plasma coagulation kinetics and an iron enhancement of coagulation. After obtaining IRB approval, we assessed coagulation kinetics and iron enhancement with viscoelastic methods in archived, citrated plasma obtained from ambulatory or hospitalized SCD patients (n = 20). All SCD patients had plasmatic hypercoagulability, and 65 % were positive for iron enhancement of coagulation. In conclusion, continuing investigation correlating such viscoelastic data with clinical symptoms may provide insight into the role played by iron in the setting of SCD, including complications such as vaso-occlusive crisis.

KW - Fibrinogen

KW - Iron

KW - Sickle cell disease

KW - Thrombelastography

UR - http://www.scopus.com/inward/record.url?scp=84931576175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931576175&partnerID=8YFLogxK

U2 - 10.1007/s11239-015-1230-6

DO - 10.1007/s11239-015-1230-6

M3 - Article

C2 - 25986992

AN - SCOPUS:84931576175

VL - 40

SP - 182

EP - 185

JO - Journal of Thrombosis and Thrombolysis

JF - Journal of Thrombosis and Thrombolysis

SN - 0929-5305

IS - 2

ER -