Significance of isolated antibody to hepatitis B core antigen determined by immune response to hepatitis B vaccination.

M. Draelos, T. Morgan, Ronald B Schifman, R. E. Sampliner

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Abstract

The immune response to hepatitis B vaccine was studied in 14 individuals with isolated, high-titer antibody to hepatitis B core antigen (anti-HBc) and examined as an indicator of this serologic pattern's significance. Four subjects demonstrated a low-titer antibody to hepatitis B surface antigen (anti-HBs) on repeated testing, and three in this subgroup had anamnestic responses (anti-HBs, 82 to 140 ratio units) after vaccination. Compared with 22 seronegative controls, the remaining ten had significantly higher anti-HBs response rates (78% vs 22%, P = .003) and median anti-HBs titers (4 vs 0 ratio units, P = .008) two weeks after vaccination. One of ten subjects had an anamnestic response, while another exhibited no response. The general pattern of anti-HBs responsiveness observed in those subjects with isolated, high-titer anti-HBc was intermediate between seronegative and anti-HBs-positive groups and may indicate a state of waning immunity after natural infection. Hepatitis B vaccination with follow-up anti-HBs testing should be done for those patients with isolated, high-titer anti-HBc to help exclude chronic infection and boost protective immunity.

Original languageEnglish (US)
Pages (from-to)1193-1195
Number of pages3
JournalJournal of the American Medical Association
Volume258
Issue number9
StatePublished - Sep 4 1987

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Hepatitis B Core Antigens
Hepatitis B
Vaccination
Antibodies
Hepatitis B Vaccines
Hepatitis B Surface Antigens
Infection
Innate Immunity
Immunity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Significance of isolated antibody to hepatitis B core antigen determined by immune response to hepatitis B vaccination. / Draelos, M.; Morgan, T.; Schifman, Ronald B; Sampliner, R. E.

In: Journal of the American Medical Association, Vol. 258, No. 9, 04.09.1987, p. 1193-1195.

Research output: Contribution to journalArticle

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