Simple and fast inverse alignment

John Kececioglu, Eagu Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

21 Scopus citations

Abstract

For as long as biologists have been computing alignments of sequences, the question of what values to use for scoring substitutions and gaps has persisted. While some choices for substitution scores are now common, largely due to convention, there is no standard for choosing gap penalties. An objective way to resolve this question is to learn the appropriate values by solving the Inverse String Alignment Problem: given examples of correct alignments, find parameter values that make the examples be optimal-scoring alignments of their strings. We present a new polynomial-time algorithm for Inverse String Alignment that is simple to implement, fast in practice, and for the first time can learn hundreds of parameters simultaneously. The approach is also flexible: minor modifications allow us to solve inverse unique alignment (find parameter values that make the examples be the unique optimal alignments of their strings), and inverse near-optimal alignment (find parameter values that make the example alignments be as close to optimal as possible). Computational results with an implementation for global alignment show that, for the first time, we can find best-possible values for all 212 parameters of the standard protein-sequence scoring-model from hundreds of alignments in a few minutes of computation.

Original languageEnglish (US)
Title of host publicationResearch in Computational Molecular Biology - 10th Annual International Conference, RECOMB 2006, Proceedings
Pages441-455
Number of pages15
DOIs
StatePublished - Jul 14 2006
Event10th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2006 - Venice, Italy
Duration: Apr 2 2006Apr 5 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3909 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other10th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2006
CountryItaly
CityVenice
Period4/2/064/5/06

Keywords

  • Affine gap penalties
  • Cutting plane algorithms
  • Linear programming
  • Parametric sequence alignment
  • Sequence analysis
  • Substitution score matrices
  • Supervised learning

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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