Simple antifungal metabolites from a marine sponge, Halichondria sp.

Hong yu Li; Shigeki Matsunaga; Nobuhiro Fusetani

doi:10.1016/0305-0491(94)90048-5

Simple antifungal metabolites from a marine sponge, Halichondria sp.

Hong yu Li, Shigeki Matsunaga, Nobuhiro Fusetani

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Three indoles, tryptophol (1), 6-bromoindole-3-carbaldehyde (2), and indole-3-carbaldehyde (3) together with p-hydroxybenzaldehyde (4) and phenylacetamide (5) have been isolated from a marine sponge, Halichondria sp. Their structures were elucidated by spectroscopic methods as well as comparison of spectral data with those reported. This is the first isolation of these five compounds from sponges, of which tryptophol (1) and phenylacetamide (5) were isolated for the first time from marine organisms. These compounds were antifungal against Mortierella ramannianus.

Original language	English (US)
Pages (from-to)	261-264
Number of pages	4
Journal	Comparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/0305-0491(94)90048-5
State	Published - Feb 1994

Keywords

6-Bromoindole-3-carbaldehyde
Antifungal metabolites
Halichondria
Indole-3-carbaldehyde
Phenylacetamide
Tryptophol
p-Hydroxybenzaldehyde

ASJC Scopus subject areas

Biochemistry
Physiology
Molecular Biology

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title = "Simple antifungal metabolites from a marine sponge, Halichondria sp.",

abstract = "Three indoles, tryptophol (1), 6-bromoindole-3-carbaldehyde (2), and indole-3-carbaldehyde (3) together with p-hydroxybenzaldehyde (4) and phenylacetamide (5) have been isolated from a marine sponge, Halichondria sp. Their structures were elucidated by spectroscopic methods as well as comparison of spectral data with those reported. This is the first isolation of these five compounds from sponges, of which tryptophol (1) and phenylacetamide (5) were isolated for the first time from marine organisms. These compounds were antifungal against Mortierella ramannianus.",

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AU - Fusetani, Nobuhiro

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N2 - Three indoles, tryptophol (1), 6-bromoindole-3-carbaldehyde (2), and indole-3-carbaldehyde (3) together with p-hydroxybenzaldehyde (4) and phenylacetamide (5) have been isolated from a marine sponge, Halichondria sp. Their structures were elucidated by spectroscopic methods as well as comparison of spectral data with those reported. This is the first isolation of these five compounds from sponges, of which tryptophol (1) and phenylacetamide (5) were isolated for the first time from marine organisms. These compounds were antifungal against Mortierella ramannianus.

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