Simulation of electrophoretic separations by the flux-corrected transport method

T. L. Sounart, J. C. Baygents

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Electrophoretic separations at typical experimental electric field strengths have been simulated by applying the flux-corrected transport (FCT) finite difference method to the transient, one-dimensional electrophoresis model. The performance of FCT on simulations of zone electrophoresis (ZE), isotachophoresis (ITP), and isoelectric focusing (IEF) has been evaluated. An FCT algorithm, with a three-point, central spatial discretization, yields numerical solutions without numerical oscillations or spurious peaks, which have plagued previously-published second-order solutions to benchmark ZE and ITP problems. Moreover, the FCT technique captures sharp zone boundaries and IEF peaks more accurately than previously-published, first-order upwind schemes. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)321-336
Number of pages16
JournalJournal of Chromatography A
Volume890
Issue number2
DOIs
StatePublished - Aug 25 2000

Keywords

  • Computer simulation
  • Electric field strength
  • Flux-corrected transport

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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