Simulation of oxygen transport to skeletal muscle by microvascular networks

T. W. Secomb, R. Hsu

Research output: Contribution to conferencePaper

Abstract

The delivery of oxygen to tissue by realistic configurations of microvessels, including arterioles and capillaries is simulated, and the dependence of the decline in arteriolar PO(2) on the oxygen demand of the tissue and on the blood flow rate is predicted. Simulations are performed for a cuboidal region of tissue containing a number of vessel segments, neglecting diffusive oxygen flux across tissue boundaries. The distribution of oxygen fluxes from the vessels is computed using a Green's function method. Simulation results show that the classical view of oxygen diffusion is far from accurate. Diffusive oxygen loss from arterioles is generally substantial. The decline in arteriolar PO(2) is of sufficient magnitude to provide a potential signal for metabolic regulation of blood flow.

Original languageEnglish (US)
Pages193-194
Number of pages2
StatePublished - Jan 1 1995
EventProceedings of the 1995 Bioengineering Conference - Beever Creek, CO, USA
Duration: Jun 28 1995Jul 2 1995

Other

OtherProceedings of the 1995 Bioengineering Conference
CityBeever Creek, CO, USA
Period6/28/957/2/95

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Secomb, T. W., & Hsu, R. (1995). Simulation of oxygen transport to skeletal muscle by microvascular networks. 193-194. Paper presented at Proceedings of the 1995 Bioengineering Conference, Beever Creek, CO, USA, .