Simultaneous association of total energy consumption and activity-related energy expenditure with risks of cardiovascular disease, cancer, and diabetes among postmenopausal women

Cheng Zheng, Shirley A. Beresford, Linda Van Horn, Lesley F. Tinker, Cynthia Thomson, Marian L. Neuhouser, Chongzhi Di, Joann E. Manson, Yasmin Mossavar-Rahmani, Rebecca Seguin, Todd Manini, Andrea Z. La Croix, Ross L. Prentice

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Total energy consumption and activity-related energy expenditure (AREE) estimates that have been calibrated using biomarkers to correct for measurement error were simultaneously associated with the risks of cardiovascular disease, cancer, and diabetes among postmenopausal women who were enrolled in theWomen's Health Initiative at 40 US clinical centers and followed from 1994 to the present. Calibrated energy consumption was found to be positively related, and AREE inversely related, to the risks of various cardiovascular diseases, cancers, and diabetes. These associations were not evident in most corresponding analyses that did not correct for measurement error. However, an important analytical caveat relates to the role of body mass index (BMI) (weight (kg)/height (m)2). In the calibrated variable analyses, BMI was regarded, along with self-reported data, as a source of information on energy consumption and physical activity, and BMI was otherwise excluded from the disease risk models. This approach cannot be fully justified with available data, and the analyses herein imply a need for improved dietary and physical activity assessment methods and for longitudinal self-reported and biomarker data to test and relax modeling assumptions. Estimated hazard ratios for 20% increases in total energy consumption and AREE, respectively, were as follows: 1.49 (95% confidence interval: 1.18, 1.88) and 0.80 (95% confidence interval: 0.69, 0.92) for total cardiovascular disease; 1.43 (95% confidence interval: 1.17, 1.73) and 0.84 (95% confidence interval: 0.73, 0.96) for total invasive cancer; and 4.17 (95% confidence interval: 2.68, 6.49) and 0.60 (95% confidence interval: 0.44, 0.83) for diabetes.

Original languageEnglish (US)
Pages (from-to)526-535
Number of pages10
JournalAmerican Journal of Epidemiology
Volume180
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Energy Metabolism
Cardiovascular Diseases
Confidence Intervals
Neoplasms
Body Mass Index
Biomarkers
Exercise
Weights and Measures
Health

Keywords

  • Body mass index
  • Cancer
  • Cardiovascular disease
  • Diabetes
  • Energy consumption
  • Hazard ratio
  • Measurement error
  • Physical activity

ASJC Scopus subject areas

  • Epidemiology

Cite this

Simultaneous association of total energy consumption and activity-related energy expenditure with risks of cardiovascular disease, cancer, and diabetes among postmenopausal women. / Zheng, Cheng; Beresford, Shirley A.; Van Horn, Linda; Tinker, Lesley F.; Thomson, Cynthia; Neuhouser, Marian L.; Di, Chongzhi; Manson, Joann E.; Mossavar-Rahmani, Yasmin; Seguin, Rebecca; Manini, Todd; La Croix, Andrea Z.; Prentice, Ross L.

In: American Journal of Epidemiology, Vol. 180, No. 5, 2014, p. 526-535.

Research output: Contribution to journalArticle

Zheng, C, Beresford, SA, Van Horn, L, Tinker, LF, Thomson, C, Neuhouser, ML, Di, C, Manson, JE, Mossavar-Rahmani, Y, Seguin, R, Manini, T, La Croix, AZ & Prentice, RL 2014, 'Simultaneous association of total energy consumption and activity-related energy expenditure with risks of cardiovascular disease, cancer, and diabetes among postmenopausal women', American Journal of Epidemiology, vol. 180, no. 5, pp. 526-535. https://doi.org/10.1093/aje/kwu152
Zheng, Cheng ; Beresford, Shirley A. ; Van Horn, Linda ; Tinker, Lesley F. ; Thomson, Cynthia ; Neuhouser, Marian L. ; Di, Chongzhi ; Manson, Joann E. ; Mossavar-Rahmani, Yasmin ; Seguin, Rebecca ; Manini, Todd ; La Croix, Andrea Z. ; Prentice, Ross L. / Simultaneous association of total energy consumption and activity-related energy expenditure with risks of cardiovascular disease, cancer, and diabetes among postmenopausal women. In: American Journal of Epidemiology. 2014 ; Vol. 180, No. 5. pp. 526-535.
@article{e76816d459474e8997e87f5647834cd9,
title = "Simultaneous association of total energy consumption and activity-related energy expenditure with risks of cardiovascular disease, cancer, and diabetes among postmenopausal women",
abstract = "Total energy consumption and activity-related energy expenditure (AREE) estimates that have been calibrated using biomarkers to correct for measurement error were simultaneously associated with the risks of cardiovascular disease, cancer, and diabetes among postmenopausal women who were enrolled in theWomen's Health Initiative at 40 US clinical centers and followed from 1994 to the present. Calibrated energy consumption was found to be positively related, and AREE inversely related, to the risks of various cardiovascular diseases, cancers, and diabetes. These associations were not evident in most corresponding analyses that did not correct for measurement error. However, an important analytical caveat relates to the role of body mass index (BMI) (weight (kg)/height (m)2). In the calibrated variable analyses, BMI was regarded, along with self-reported data, as a source of information on energy consumption and physical activity, and BMI was otherwise excluded from the disease risk models. This approach cannot be fully justified with available data, and the analyses herein imply a need for improved dietary and physical activity assessment methods and for longitudinal self-reported and biomarker data to test and relax modeling assumptions. Estimated hazard ratios for 20{\%} increases in total energy consumption and AREE, respectively, were as follows: 1.49 (95{\%} confidence interval: 1.18, 1.88) and 0.80 (95{\%} confidence interval: 0.69, 0.92) for total cardiovascular disease; 1.43 (95{\%} confidence interval: 1.17, 1.73) and 0.84 (95{\%} confidence interval: 0.73, 0.96) for total invasive cancer; and 4.17 (95{\%} confidence interval: 2.68, 6.49) and 0.60 (95{\%} confidence interval: 0.44, 0.83) for diabetes.",
keywords = "Body mass index, Cancer, Cardiovascular disease, Diabetes, Energy consumption, Hazard ratio, Measurement error, Physical activity",
author = "Cheng Zheng and Beresford, {Shirley A.} and {Van Horn}, Linda and Tinker, {Lesley F.} and Cynthia Thomson and Neuhouser, {Marian L.} and Chongzhi Di and Manson, {Joann E.} and Yasmin Mossavar-Rahmani and Rebecca Seguin and Todd Manini and {La Croix}, {Andrea Z.} and Prentice, {Ross L.}",
year = "2014",
doi = "10.1093/aje/kwu152",
language = "English (US)",
volume = "180",
pages = "526--535",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Simultaneous association of total energy consumption and activity-related energy expenditure with risks of cardiovascular disease, cancer, and diabetes among postmenopausal women

AU - Zheng, Cheng

AU - Beresford, Shirley A.

AU - Van Horn, Linda

AU - Tinker, Lesley F.

AU - Thomson, Cynthia

AU - Neuhouser, Marian L.

AU - Di, Chongzhi

AU - Manson, Joann E.

AU - Mossavar-Rahmani, Yasmin

AU - Seguin, Rebecca

AU - Manini, Todd

AU - La Croix, Andrea Z.

AU - Prentice, Ross L.

PY - 2014

Y1 - 2014

N2 - Total energy consumption and activity-related energy expenditure (AREE) estimates that have been calibrated using biomarkers to correct for measurement error were simultaneously associated with the risks of cardiovascular disease, cancer, and diabetes among postmenopausal women who were enrolled in theWomen's Health Initiative at 40 US clinical centers and followed from 1994 to the present. Calibrated energy consumption was found to be positively related, and AREE inversely related, to the risks of various cardiovascular diseases, cancers, and diabetes. These associations were not evident in most corresponding analyses that did not correct for measurement error. However, an important analytical caveat relates to the role of body mass index (BMI) (weight (kg)/height (m)2). In the calibrated variable analyses, BMI was regarded, along with self-reported data, as a source of information on energy consumption and physical activity, and BMI was otherwise excluded from the disease risk models. This approach cannot be fully justified with available data, and the analyses herein imply a need for improved dietary and physical activity assessment methods and for longitudinal self-reported and biomarker data to test and relax modeling assumptions. Estimated hazard ratios for 20% increases in total energy consumption and AREE, respectively, were as follows: 1.49 (95% confidence interval: 1.18, 1.88) and 0.80 (95% confidence interval: 0.69, 0.92) for total cardiovascular disease; 1.43 (95% confidence interval: 1.17, 1.73) and 0.84 (95% confidence interval: 0.73, 0.96) for total invasive cancer; and 4.17 (95% confidence interval: 2.68, 6.49) and 0.60 (95% confidence interval: 0.44, 0.83) for diabetes.

AB - Total energy consumption and activity-related energy expenditure (AREE) estimates that have been calibrated using biomarkers to correct for measurement error were simultaneously associated with the risks of cardiovascular disease, cancer, and diabetes among postmenopausal women who were enrolled in theWomen's Health Initiative at 40 US clinical centers and followed from 1994 to the present. Calibrated energy consumption was found to be positively related, and AREE inversely related, to the risks of various cardiovascular diseases, cancers, and diabetes. These associations were not evident in most corresponding analyses that did not correct for measurement error. However, an important analytical caveat relates to the role of body mass index (BMI) (weight (kg)/height (m)2). In the calibrated variable analyses, BMI was regarded, along with self-reported data, as a source of information on energy consumption and physical activity, and BMI was otherwise excluded from the disease risk models. This approach cannot be fully justified with available data, and the analyses herein imply a need for improved dietary and physical activity assessment methods and for longitudinal self-reported and biomarker data to test and relax modeling assumptions. Estimated hazard ratios for 20% increases in total energy consumption and AREE, respectively, were as follows: 1.49 (95% confidence interval: 1.18, 1.88) and 0.80 (95% confidence interval: 0.69, 0.92) for total cardiovascular disease; 1.43 (95% confidence interval: 1.17, 1.73) and 0.84 (95% confidence interval: 0.73, 0.96) for total invasive cancer; and 4.17 (95% confidence interval: 2.68, 6.49) and 0.60 (95% confidence interval: 0.44, 0.83) for diabetes.

KW - Body mass index

KW - Cancer

KW - Cardiovascular disease

KW - Diabetes

KW - Energy consumption

KW - Hazard ratio

KW - Measurement error

KW - Physical activity

UR - http://www.scopus.com/inward/record.url?scp=84907339514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907339514&partnerID=8YFLogxK

U2 - 10.1093/aje/kwu152

DO - 10.1093/aje/kwu152

M3 - Article

C2 - 25016533

AN - SCOPUS:84907339514

VL - 180

SP - 526

EP - 535

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 5

ER -