Simultaneous confidence bounds for low-dose risk assessment with nonquantal data

Walter W Piegorsch, R. Webster West, Wei Pan, Ralph L. Kodell

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We study the use of simultaneous confidence bounds for making low-dose inferences in quantitative risk analysis. Confidence limits are constructed for outcomes measured on a continuous scale, assuming a simple linear model for the observed response. From the simultaneous confidence hounds, simultaneous lower limits an the benchmark dose associated with a particular risk are also constructed.

Original languageEnglish (US)
Pages (from-to)17-31
Number of pages15
JournalJournal of Biopharmaceutical Statistics
Volume15
Issue number1
DOIs
Publication statusPublished - 2005
Externally publishedYes

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Keywords

  • Benchmark dose (BMD)
  • BMDL
  • Low-dose extrapolation
  • Noncentrality parameter
  • Nonquantal dose response
  • Safety assessment
  • Simultaneous confidence bands

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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