Simultaneous detection of multiple contrast agents with photoacoustic spectroscopy

Daniel R. Bauer, Leonardo G. Montilla, Mir Salek, Nathan Allen, Kaushal Rege, Russell S. Witte

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Early detection of cancer is important for survival, and multiple targeted contrast agents can be used for advanced cellular profiling. Photoacoustic (PA) imaging is effective at imaging optically-absorbing contrast agents. In this study, we present simulated and experimental results using spectral decomposition to separate the PA absorption spectrum into components from individual contrast agents. The original co-localized concentration of each agent is then simultaneously reconstructed. Monte Carlo simulations were performed to estimate wavelength-dependent fluences in the sample. In phantom experiments, the concentration of two contrast agents (gold nanorods with different absorption spectra) and a background absorbing dye (India Ink) were reconstructed. Finally, we implemented our algorithm in a mouse after injections of gold nanorods with absorption peaks of 750 and 810 nm. The concentration of each nanoparticle was identified from the endogenous background signal with a signal-to-noise ratio of greater than 25 dB.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages1421-1424
Number of pages4
DOIs
StatePublished - Dec 1 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Keywords

  • breast cancer
  • gold nanorods
  • molecular imaging
  • optoacoustic
  • spectral decomposition algorithm

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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  • Cite this

    Bauer, D. R., Montilla, L. G., Salek, M., Allen, N., Rege, K., & Witte, R. S. (2012). Simultaneous detection of multiple contrast agents with photoacoustic spectroscopy. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 1421-1424). [6562019] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2012.0355