Simultaneous measurement of lipid and aqueous layers of tear film using optical coherence tomography and statistical decision theory

Jinxin Huang, Eric Clarkson, Matthew Kupinski, Jannick P. Rolland

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The prevalence of Dry Eye Disease (DED) in the USA is approximately 40 million in aging adults with about $3.8 billion economic burden. However, a comprehensive understanding of tear film dynamics, which is the prerequisite to advance the management of DED, is yet to be realized. To extend our understanding of tear film dynamics, we investigate the simultaneous estimation of the lipid and aqueous layers thicknesses with the combination of optical coherence tomography (OCT) and statistical decision theory. In specific, we develop a mathematical model for Fourier-domain OCT where we take into account the different statistical processes associated with the imaging chain. We formulate the first-order and second-order statistical quantities of the output of the OCT system, which can generate some simulated OCT spectra. A tear film model, which includes a lipid and aqueous layer on top of a rough corneal surface, is the object being imaged. Then we further implement a Maximum-likelihood (ML) estimator to interpret the simulated OCT data to estimate the thicknesses of both layers of the tear film. Results show that an axial resolution of 1 μm allows estimates down to nanometers scale. We use the root mean square error of the estimates as a metric to evaluate the system parameters, such as the tradeoff between the imaging speed and the precision of estimation. This framework further provides the theoretical basics to optimize the imaging setup for a specific thickness estimation task.

Original languageEnglish (US)
Title of host publicationDesign and Quality for Biomedical Technologies VII
PublisherSPIE
ISBN (Print)9780819498496
DOIs
StatePublished - Jan 1 2014
EventDesign and Quality for Biomedical Technologies VII - San Francisco, CA, United States
Duration: Feb 1 2014Feb 2 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8936
ISSN (Print)1605-7422

Other

OtherDesign and Quality for Biomedical Technologies VII
CountryUnited States
CitySan Francisco, CA
Period2/1/142/2/14

Keywords

  • Maximum-likelihood estimation
  • Optical coherence tomography
  • Statistical decision theory
  • Tear film dynamics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Huang, J., Clarkson, E., Kupinski, M., & Rolland, J. P. (2014). Simultaneous measurement of lipid and aqueous layers of tear film using optical coherence tomography and statistical decision theory. In Design and Quality for Biomedical Technologies VII [89360A] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8936). SPIE. https://doi.org/10.1117/12.2041898