Simultaneous Pancreas and Kidney Transplantation—Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry

Angelika C Gruessner, Mark R. Laftavi, Oleh Pankewycz, Rainer W G Gruessner

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Purpose of Review: Pancreas transplantation remains the best long-term treatment option to achieve euglycemia and freedom from insulin in patients with labile diabetes mellitus. It is an approved procedure for type 1 (T1DM), but it is still considered controversial for type 2 diabetes mellitus (T2DM). Recent Findings: This study analyzed all primary deceased donor pancreas transplants in patients with T2DM reported to IPTR/UNOS between 1995 and 2015. Characteristics, outcomes, and risk factors over time were determined using univariate and multivariate methods. The focus was on simultaneous pancreas/kidney (SPK) transplants, the most common pancreas transplant category. Patient, pancreas, and kidney graft survival rates increased significantly over time and reached 95.8, 83.3, and 91.1%, respectively, at 3 years posttransplant for transplants performed between 2009 and 2015. Summary: SPK is a safe procedure with excellent pancreas and kidney graft outcome in patients with T2DM. The procedure restores euglycemia and freedom from insulin and dialysis. Based on our results, SPK should be offered to more uremic patients with labile T2DM.

Original languageEnglish (US)
Article number44
JournalCurrent Diabetes Reports
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Registries
Pancreas
Transplants
Kidney
Therapeutics
Insulin
Pancreas Transplantation
Graft Survival
Dialysis
Diabetes Mellitus
Survival Rate
Tissue Donors

Keywords

  • Graft function
  • Kidney transplants
  • Pancreas transplants
  • Patient survival
  • Risk factors
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{53aacf27a6df418a8acc360a70443e58,
title = "Simultaneous Pancreas and Kidney Transplantation—Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry",
abstract = "Purpose of Review: Pancreas transplantation remains the best long-term treatment option to achieve euglycemia and freedom from insulin in patients with labile diabetes mellitus. It is an approved procedure for type 1 (T1DM), but it is still considered controversial for type 2 diabetes mellitus (T2DM). Recent Findings: This study analyzed all primary deceased donor pancreas transplants in patients with T2DM reported to IPTR/UNOS between 1995 and 2015. Characteristics, outcomes, and risk factors over time were determined using univariate and multivariate methods. The focus was on simultaneous pancreas/kidney (SPK) transplants, the most common pancreas transplant category. Patient, pancreas, and kidney graft survival rates increased significantly over time and reached 95.8, 83.3, and 91.1{\%}, respectively, at 3 years posttransplant for transplants performed between 2009 and 2015. Summary: SPK is a safe procedure with excellent pancreas and kidney graft outcome in patients with T2DM. The procedure restores euglycemia and freedom from insulin and dialysis. Based on our results, SPK should be offered to more uremic patients with labile T2DM.",
keywords = "Graft function, Kidney transplants, Pancreas transplants, Patient survival, Risk factors, Type 2 diabetes mellitus",
author = "Gruessner, {Angelika C} and Laftavi, {Mark R.} and Oleh Pankewycz and Gruessner, {Rainer W G}",
year = "2017",
month = "6",
day = "1",
doi = "10.1007/s11892-017-0864-5",
language = "English (US)",
volume = "17",
journal = "Current Diabetes Reports",
issn = "1534-4827",
publisher = "Current Medicine Group",
number = "6",

}

TY - JOUR

T1 - Simultaneous Pancreas and Kidney Transplantation—Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry

AU - Gruessner, Angelika C

AU - Laftavi, Mark R.

AU - Pankewycz, Oleh

AU - Gruessner, Rainer W G

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Purpose of Review: Pancreas transplantation remains the best long-term treatment option to achieve euglycemia and freedom from insulin in patients with labile diabetes mellitus. It is an approved procedure for type 1 (T1DM), but it is still considered controversial for type 2 diabetes mellitus (T2DM). Recent Findings: This study analyzed all primary deceased donor pancreas transplants in patients with T2DM reported to IPTR/UNOS between 1995 and 2015. Characteristics, outcomes, and risk factors over time were determined using univariate and multivariate methods. The focus was on simultaneous pancreas/kidney (SPK) transplants, the most common pancreas transplant category. Patient, pancreas, and kidney graft survival rates increased significantly over time and reached 95.8, 83.3, and 91.1%, respectively, at 3 years posttransplant for transplants performed between 2009 and 2015. Summary: SPK is a safe procedure with excellent pancreas and kidney graft outcome in patients with T2DM. The procedure restores euglycemia and freedom from insulin and dialysis. Based on our results, SPK should be offered to more uremic patients with labile T2DM.

AB - Purpose of Review: Pancreas transplantation remains the best long-term treatment option to achieve euglycemia and freedom from insulin in patients with labile diabetes mellitus. It is an approved procedure for type 1 (T1DM), but it is still considered controversial for type 2 diabetes mellitus (T2DM). Recent Findings: This study analyzed all primary deceased donor pancreas transplants in patients with T2DM reported to IPTR/UNOS between 1995 and 2015. Characteristics, outcomes, and risk factors over time were determined using univariate and multivariate methods. The focus was on simultaneous pancreas/kidney (SPK) transplants, the most common pancreas transplant category. Patient, pancreas, and kidney graft survival rates increased significantly over time and reached 95.8, 83.3, and 91.1%, respectively, at 3 years posttransplant for transplants performed between 2009 and 2015. Summary: SPK is a safe procedure with excellent pancreas and kidney graft outcome in patients with T2DM. The procedure restores euglycemia and freedom from insulin and dialysis. Based on our results, SPK should be offered to more uremic patients with labile T2DM.

KW - Graft function

KW - Kidney transplants

KW - Pancreas transplants

KW - Patient survival

KW - Risk factors

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=85019033351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019033351&partnerID=8YFLogxK

U2 - 10.1007/s11892-017-0864-5

DO - 10.1007/s11892-017-0864-5

M3 - Review article

C2 - 28478590

AN - SCOPUS:85019033351

VL - 17

JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

IS - 6

M1 - 44

ER -