Simultaneous Pancreas and Kidney Transplantation—Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry

Angelika C. Gruessner, Mark R. Laftavi, Oleh Pankewycz, Rainer W.G. Gruessner

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Purpose of Review: Pancreas transplantation remains the best long-term treatment option to achieve euglycemia and freedom from insulin in patients with labile diabetes mellitus. It is an approved procedure for type 1 (T1DM), but it is still considered controversial for type 2 diabetes mellitus (T2DM). Recent Findings: This study analyzed all primary deceased donor pancreas transplants in patients with T2DM reported to IPTR/UNOS between 1995 and 2015. Characteristics, outcomes, and risk factors over time were determined using univariate and multivariate methods. The focus was on simultaneous pancreas/kidney (SPK) transplants, the most common pancreas transplant category. Patient, pancreas, and kidney graft survival rates increased significantly over time and reached 95.8, 83.3, and 91.1%, respectively, at 3 years posttransplant for transplants performed between 2009 and 2015. Summary: SPK is a safe procedure with excellent pancreas and kidney graft outcome in patients with T2DM. The procedure restores euglycemia and freedom from insulin and dialysis. Based on our results, SPK should be offered to more uremic patients with labile T2DM.

Original languageEnglish (US)
Article number44
JournalCurrent diabetes reports
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2017

Keywords

  • Graft function
  • Kidney transplants
  • Pancreas transplants
  • Patient survival
  • Risk factors
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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