Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments

Shue Wang, Reza Riahi, Na Li, Donna D. Zhang, Pak Kin Wong

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A gold nanorod-locked nucleic acid nanobiosensor for dynamic single-cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single-cell level.

Original languageEnglish (US)
Pages (from-to)6034-6038
Number of pages5
JournalAdvanced Materials
Volume27
Issue number39
DOIs
StatePublished - Oct 1 2015

Keywords

  • biosensors
  • locked nucleic acids
  • nanoparticles
  • single cells
  • tissue microenvironments

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments'. Together they form a unique fingerprint.

Cite this