Abstract
Using a murine model of melanoma we tested the effect of D-penicillamine administered in repetitive, daily injections, or as a single large dose injected either in saline or in a biodegradable polymer. We also studied the effect of a single intratumoral injection of benzyl-ester-D-penicillamine on the growth of the tumor. Daily injections of the drug or its administration in a polymer or benzyl-ester of D-penicillamine were all significantly inhibitory. The inhibitory effect manifested 4-5 days after injection. The inhibition lasted 8-10 days. There was no evidence of local or systemic toxicity and no changes in body weight. Several possible mechanisms for the inhibitory effect are presented.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 757-762 |
| Number of pages | 6 |
| Journal | Anti-Cancer Drugs |
| Volume | 16 |
| Issue number | 7 |
| DOIs | |
| State | Published - Aug 2005 |
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Keywords
- Angiogenesis
- Collagen structural stability
- D-penicillamine
- D-penicillamine benzyl ester
- Lysyl oxidase
- Matrix metalloproteinase
- Melanoma
- Murine model
- Schiff base cross-links
ASJC Scopus subject areas
- Pharmacology
- Cancer Research
- Oncology
Cite this
Single intratumoral injection of long-acting benzyl ester of D-penicillamine inhibits the growth of melanoma tumor in mice. / Chvapil, Milos; Dorr, Robert T.
In: Anti-Cancer Drugs, Vol. 16, No. 7, 08.2005, p. 757-762.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single intratumoral injection of long-acting benzyl ester of D-penicillamine inhibits the growth of melanoma tumor in mice
AU - Chvapil, Milos
AU - Dorr, Robert T
PY - 2005/8
Y1 - 2005/8
N2 - Using a murine model of melanoma we tested the effect of D-penicillamine administered in repetitive, daily injections, or as a single large dose injected either in saline or in a biodegradable polymer. We also studied the effect of a single intratumoral injection of benzyl-ester-D-penicillamine on the growth of the tumor. Daily injections of the drug or its administration in a polymer or benzyl-ester of D-penicillamine were all significantly inhibitory. The inhibitory effect manifested 4-5 days after injection. The inhibition lasted 8-10 days. There was no evidence of local or systemic toxicity and no changes in body weight. Several possible mechanisms for the inhibitory effect are presented.
AB - Using a murine model of melanoma we tested the effect of D-penicillamine administered in repetitive, daily injections, or as a single large dose injected either in saline or in a biodegradable polymer. We also studied the effect of a single intratumoral injection of benzyl-ester-D-penicillamine on the growth of the tumor. Daily injections of the drug or its administration in a polymer or benzyl-ester of D-penicillamine were all significantly inhibitory. The inhibitory effect manifested 4-5 days after injection. The inhibition lasted 8-10 days. There was no evidence of local or systemic toxicity and no changes in body weight. Several possible mechanisms for the inhibitory effect are presented.
KW - Angiogenesis
KW - Collagen structural stability
KW - D-penicillamine
KW - D-penicillamine benzyl ester
KW - Lysyl oxidase
KW - Matrix metalloproteinase
KW - Melanoma
KW - Murine model
KW - Schiff base cross-links
UR - http://www.scopus.com/inward/record.url?scp=23344451977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23344451977&partnerID=8YFLogxK
U2 - 10.1097/01.cad.0000171767.59187.c2
DO - 10.1097/01.cad.0000171767.59187.c2
M3 - Article
VL - 16
SP - 757
EP - 762
JO - Anti-Cancer Drugs
JF - Anti-Cancer Drugs
SN - 0959-4973
IS - 7
ER -