Single intratumoral injection of long-acting benzyl ester of D-penicillamine inhibits the growth of melanoma tumor in mice

Milos Chvapil, Robert Dorr

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Using a murine model of melanoma we tested the effect of D-penicillamine administered in repetitive, daily injections, or as a single large dose injected either in saline or in a biodegradable polymer. We also studied the effect of a single intratumoral injection of benzyl-ester-D-penicillamine on the growth of the tumor. Daily injections of the drug or its administration in a polymer or benzyl-ester of D-penicillamine were all significantly inhibitory. The inhibitory effect manifested 4-5 days after injection. The inhibition lasted 8-10 days. There was no evidence of local or systemic toxicity and no changes in body weight. Several possible mechanisms for the inhibitory effect are presented.

Original languageEnglish (US)
Pages (from-to)757-762
Number of pages6
JournalAnti-cancer drugs
Volume16
Issue number7
DOIs
StatePublished - Aug 1 2005

Keywords

  • Angiogenesis
  • Collagen structural stability
  • D-penicillamine
  • D-penicillamine benzyl ester
  • Lysyl oxidase
  • Matrix metalloproteinase
  • Melanoma
  • Murine model
  • Schiff base cross-links

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research

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