Sirtuin inhibitor sirtinol is an intracellular iron chelator

R. Gautam, E. A. Akam, A. V. Astashkin, J. J. Loughrey, Elisa Tomat

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is

Original languageEnglish (US)
Pages (from-to)5104-5107
Number of pages4
JournalChemical Communications
Volume51
Issue number24
DOIs
StatePublished - 2015

Fingerprint

Chelating Agents
Iron
Aging of materials
Proteins
sirtinol

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Gautam, R., Akam, E. A., Astashkin, A. V., Loughrey, J. J., & Tomat, E. (2015). Sirtuin inhibitor sirtinol is an intracellular iron chelator. Chemical Communications, 51(24), 5104-5107. https://doi.org/10.1039/c5cc00829h

Sirtuin inhibitor sirtinol is an intracellular iron chelator. / Gautam, R.; Akam, E. A.; Astashkin, A. V.; Loughrey, J. J.; Tomat, Elisa.

In: Chemical Communications, Vol. 51, No. 24, 2015, p. 5104-5107.

Research output: Contribution to journalArticle

Gautam, R, Akam, EA, Astashkin, AV, Loughrey, JJ & Tomat, E 2015, 'Sirtuin inhibitor sirtinol is an intracellular iron chelator', Chemical Communications, vol. 51, no. 24, pp. 5104-5107. https://doi.org/10.1039/c5cc00829h
Gautam, R. ; Akam, E. A. ; Astashkin, A. V. ; Loughrey, J. J. ; Tomat, Elisa. / Sirtuin inhibitor sirtinol is an intracellular iron chelator. In: Chemical Communications. 2015 ; Vol. 51, No. 24. pp. 5104-5107.
@article{6d86a03e89284137ba14abb61d55b0df,
title = "Sirtuin inhibitor sirtinol is an intracellular iron chelator",
abstract = "Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is",
author = "R. Gautam and Akam, {E. A.} and Astashkin, {A. V.} and Loughrey, {J. J.} and Elisa Tomat",
year = "2015",
doi = "10.1039/c5cc00829h",
language = "English (US)",
volume = "51",
pages = "5104--5107",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "24",

}

TY - JOUR

T1 - Sirtuin inhibitor sirtinol is an intracellular iron chelator

AU - Gautam, R.

AU - Akam, E. A.

AU - Astashkin, A. V.

AU - Loughrey, J. J.

AU - Tomat, Elisa

PY - 2015

Y1 - 2015

N2 - Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is

AB - Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is

UR - http://www.scopus.com/inward/record.url?scp=84924690799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924690799&partnerID=8YFLogxK

U2 - 10.1039/c5cc00829h

DO - 10.1039/c5cc00829h

M3 - Article

VL - 51

SP - 5104

EP - 5107

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 24

ER -