Abstract
Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5104-5107 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 51 |
| Issue number | 24 |
| DOIs | |
| State | Published - 2015 |
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ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Ceramics and Composites
- Electronic, Optical and Magnetic Materials
- Surfaces, Coatings and Films
- Materials Chemistry
- Metals and Alloys
Cite this
Sirtuin inhibitor sirtinol is an intracellular iron chelator. / Gautam, R.; Akam, E. A.; Astashkin, A. V.; Loughrey, J. J.; Tomat, Elisa.
In: Chemical Communications, Vol. 51, No. 24, 2015, p. 5104-5107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sirtuin inhibitor sirtinol is an intracellular iron chelator
AU - Gautam, R.
AU - Akam, E. A.
AU - Astashkin, A. V.
AU - Loughrey, J. J.
AU - Tomat, Elisa
PY - 2015
Y1 - 2015
N2 - Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is
AB - Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is
UR - http://www.scopus.com/inward/record.url?scp=84924690799&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924690799&partnerID=8YFLogxK
U2 - 10.1039/c5cc00829h
DO - 10.1039/c5cc00829h
M3 - Article
C2 - 25715179
AN - SCOPUS:84924690799
VL - 51
SP - 5104
EP - 5107
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 24
ER -