Sirtuin inhibitor sirtinol is an intracellular iron chelator

R. Gautam, E. A. Akam, A. V. Astashkin, J. J. Loughrey, E. Tomat

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is

Original languageEnglish (US)
Pages (from-to)5104-5107
Number of pages4
JournalChemical Communications
Volume51
Issue number24
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Gautam, R., Akam, E. A., Astashkin, A. V., Loughrey, J. J., & Tomat, E. (2015). Sirtuin inhibitor sirtinol is an intracellular iron chelator. Chemical Communications, 51(24), 5104-5107. https://doi.org/10.1039/c5cc00829h