Sirtuin inhibitor sirtinol is an intracellular iron chelator

R. Gautam; E. A. Akam; A. V. Astashkin; J. J. Loughrey; E. Tomat

doi:10.1039/c5cc00829h

Sirtuin inhibitor sirtinol is an intracellular iron chelator

R. Gautam, E. A. Akam, A. V. Astashkin, J. J. Loughrey, E. Tomat

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is

Original language	English (US)
Pages (from-to)	5104-5107
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	24
DOIs	https://doi.org/10.1039/c5cc00829h
State	Published - 2015

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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AU - Loughrey, J. J.

AU - Tomat, E.

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AB - Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda. This journal is

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Sirtuin inhibitor sirtinol is an intracellular iron chelator

Abstract

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