Site discrepancy of synonymous codon usage in SARS coronavirus and other viruses in Coronaviridae

Tong Zhou, Wanjun Gu, Jianmin Ma, Xiao Sun, Zuhong Lu

Research output: Contribution to journalArticle


The synonymous codon usage in the translational initiation and termination regions of genes of severe acute respiratory syndrome (SARS) coronavirus and five other viruses in Coronaviridae was systematically analyzed. The results indicate that most minor codons for these coronaviruses are preferentially used in the initial and terminal region. The minor codons preferentially used in the initial region are thought to have a negative effect on gene expression, which can be explained by the minor codon modulator hypothesis. It also indicates that the minor codons preferentially used in the terminal region may regulate the level of gene expression. The proposed results strongly imply that the minor codon modulator hypothesis can be applied to both some bacteria and some viruses.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalJournal of Southeast University (English Edition)
Issue number2
StatePublished - Jun 1 2005



  • Codon usage
  • Coronavirus
  • Gene expression
  • Severe acute respiratory syndrome (SARS)
  • Site discrepancy

ASJC Scopus subject areas

  • Engineering(all)

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