Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man.

S. Lillioja, A. A. Young, C. L. Culter, J. L. Ivy, W. G. Abbott, J. K. Zawadzki, H. Yki-Järvinen, L. Christin, T. W. Secomb, C. Bogardus

Research output: Contribution to journalArticle

631 Scopus citations

Abstract

We have compared the capillary density and muscle fiber type of musculus vastus lateralis with in vivo insulin action determined by the euglycemic clamp (M value) in 23 Caucasians and 41 Pima Indian nondiabetic men. M value was significantly correlated with capillary density (r = 0.63; P less than or equal to 0.0001), percent type I fibers (r = 0.29; P less than 0.02), and percent type 2B fibers (r = -0.38; P less than 0.003). Fasting plasma glucose and insulin concentrations were significantly negatively correlated with capillary density (r = -0.46, P less than or equal to 0.0001; r = -0.47, P less than or equal to 0.0001, respectively). Waist circumference/thigh circumference ratio was correlated with percent type 1 fibers (r = -0.39; P less than 0.002). These results suggest that diffusion distance from capillary to muscle cells or some associated biochemical change, and fiber type, could play a role in determining in vivo insulin action. The association of muscle fiber type with body fat distribution may indicate that central obesity is only one aspect of a more generalized metabolic syndrome. The data may provide at least a partial explanation for the insulin resistance associated with obesity and for the altered kinetics of insulin action in the obese.

Original languageEnglish (US)
Pages (from-to)415-424
Number of pages10
JournalThe Journal of clinical investigation
Volume80
Issue number2
DOIs
StatePublished - Aug 1987

ASJC Scopus subject areas

  • Medicine(all)

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    Lillioja, S., Young, A. A., Culter, C. L., Ivy, J. L., Abbott, W. G., Zawadzki, J. K., Yki-Järvinen, H., Christin, L., Secomb, T. W., & Bogardus, C. (1987). Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. The Journal of clinical investigation, 80(2), 415-424. https://doi.org/10.1172/JCI113088