Skeletal muscle insulin resistance is fundamental to the cardiometabolic syndrome.

Ravi Nistala, Craig S Stump

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The cardiometabolic syndrome is associated with insulin resistance and a dysregulation of glucose and lipid metabolism that occurs in multiple tissues. Of these, skeletal muscle is the most abundant insulin-sensitive tissue, handling > 40% of the postprandial glucose uptake, while consuming 20% of the body's energy. The inability to efficiently take up and store fuel, and to transition from fat to glucose as the primary source of fuel during times of plenty (increased insulin), has been termed metabolic inflexibility. This resistance to insulin is thought to be a major contributor to the whole-body metabolic dysregulation that leads to increased cardiovascular risk. Recent investigation has identified specific defects in postinsulin receptor signaling in skeletal muscle from resistant humans and animals. Potential mechanisms contributing to this reduced insulin signaling and action include decreases in mitochondrial oxidative capacity, increased intramuscular lipid accumulation, increased reactive oxygen species generation, and up-regulated inflammatory pathways. Future research is focused on understanding these and other potential mechanisms to identify therapeutic targets for reducing cardiometabolic syndrome risk.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalJournal of the CardioMetabolic Syndrome
Volume1
Issue number1
DOIs
StatePublished - Dec 2006
Externally publishedYes

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Insulin Resistance
Skeletal Muscle
Insulin
Glucose
Lipid Metabolism
Reactive Oxygen Species
Fats
Lipids
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Skeletal muscle insulin resistance is fundamental to the cardiometabolic syndrome. / Nistala, Ravi; Stump, Craig S.

In: Journal of the CardioMetabolic Syndrome, Vol. 1, No. 1, 12.2006, p. 47-52.

Research output: Contribution to journalArticle

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