Skeletal muscle insulin resistance: Role of inflammatory cytokines and reactive oxygen species

Yongzhong Wei, Kemin Chen, Adam T. Whaley-Connell, Craig S Stump, Jamal A. Ibdah, James R. Sowers

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

The cardiometabolic syndrome (CMS), with its increased risk for cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD), and chronic kidney disease (CKD), has become a growing worldwide health problem. Insulin resistance is a key factor for the development of the CMS and is strongly related to obesity, hyperlipidemia, hypertension, type 2 diabetes mellitus (T2DM), CKD, and NAFLD. Insulin resistance in skeletal muscle is particularly important since it is normally responsible for more than 75% of all insulin-mediated glucose disposal. However, the molecular mechanisms responsible for skeletal muscle insulin resistance remain poorly defined. Accumulating evidence indicates that low-grade chronic inflammation and oxidative stress play fundamental roles in the development of insulin resistance, and inflammatory cytokines likely contribute to the link between inflammation, oxidative stress, and skeletal muscle insulin resistance. Understanding the mechanisms by which skeletal muscle tissue develops resistance to insulin will provide attractive targets for interventions, which may ultimately curb this serious problem. This review is focused on the effects of inflammatory cytokines and oxidative stress on insulin signaling in skeletal muscle and consequent development of insulin resistance.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume294
Issue number3
DOIs
StatePublished - Mar 2008

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Insulin Resistance
Reactive Oxygen Species
Skeletal Muscle
Cytokines
Oxidative Stress
Chronic Renal Insufficiency
Insulin
Inflammation
Muscle Development
Hyperlipidemias
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Obesity
Hypertension
Glucose
Muscles

ASJC Scopus subject areas

  • Physiology

Cite this

Skeletal muscle insulin resistance : Role of inflammatory cytokines and reactive oxygen species. / Wei, Yongzhong; Chen, Kemin; Whaley-Connell, Adam T.; Stump, Craig S; Ibdah, Jamal A.; Sowers, James R.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 294, No. 3, 03.2008.

Research output: Contribution to journalArticle

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