Skin and soft tissue infections

Anne Spichler Moffarah, Mayar Al Mohajer, Bonnie L Hurwitz, David G Armstrong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The skin is colonized by a diverse collection of microorganisms which, for the most part, peacefully coexist with their hosts. Skin and soft tissue infections (SSTIs) encompass a variety of conditions; in immunocompromised hosts, SSTIs can be caused by diverse microorganisms-most commonly bacteria, but also fungi, viruses, mycobacteria, and protozoa. The diagnosis of SSTIs is difficult because they may commonly masquerade as other clinical syndromes or can be a manifestation of systemic disease. In immunocompromised hosts, SSTI poses a major diagnostic challenge, and clinical dermatological assessment should be initially performed; to better identify the pathogen and to lead to appropriate treatment, etiology should include cultures of lesions and blood, biopsy with histology, specific microbiological analysis with special stains, molecular techniques, and antigen-detection methodologies. Here, we reviewed the epidemiology, pathophysiology, clinical presentation, and diagnostic techniques, including molecular biological techniques, used for SSTIs, with a focus on the immunocompromised host, such as patients with cellular immunodeficiency, HIV, and diabetic foot infection.

Original languageEnglish (US)
Article numberDMIH2-0014-2015
JournalMicrobiology spectrum
Volume4
Issue number4
DOIs
StatePublished - 2016

Fingerprint

Soft Tissue Infections
skin
Skin
Immunocompromised Host
Molecular Diagnostic Techniques
microorganism
Diabetic Foot
etiology
histology
Mycobacterium
epidemiology
human immunodeficiency virus
antigen
lesion
tissue
infection
Histology
virus
Epidemiology
Fungi

ASJC Scopus subject areas

  • Physiology
  • Ecology
  • Immunology and Microbiology(all)
  • Genetics
  • Cell Biology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Skin and soft tissue infections. / Moffarah, Anne Spichler; Al Mohajer, Mayar; Hurwitz, Bonnie L; Armstrong, David G.

In: Microbiology spectrum, Vol. 4, No. 4, DMIH2-0014-2015, 2016.

Research output: Contribution to journalArticle

Moffarah, Anne Spichler ; Al Mohajer, Mayar ; Hurwitz, Bonnie L ; Armstrong, David G. / Skin and soft tissue infections. In: Microbiology spectrum. 2016 ; Vol. 4, No. 4.
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