Abstract
Introduction: This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia over 15 years of follow-up. Methods: A total of 1667 Atherosclerosis Risk in Communities Study participants underwent in-home polysomnography (1996-1998) and were followed for dementia. Dementia was defined by (1) hospitalization diagnosis codes (1996-2012) and (2) a comprehensive neurocognitive examination (2011-2013) with adjudication. Results: OSA and sleep duration were not associated with risk of incident dementia. When using adjudicated outcomes, severe OSA (≥30 vs. <5 apnea-hypopnea events/hour) was associated with higher risk of all-cause dementia (risk ratio [95% confidence interval], 2.35 [1.06-5.18]) and Alzheimer's disease dementia (1.66 [1.03-2.68]); associations were attenuated with cardiovascular risk factor adjustment. Sleeping <7 versus 8 to ≤9 hours was associated with higher risk of all-cause dementia (2.00 [1.03-3.86]). Discussion: When adjudicated outcome definitions were used, late-midlife OSA and short sleep duration were associated with all-cause and Alzheimer's disease dementia in later life.
| Original language | English (US) |
|---|---|
| Journal | Alzheimer's and Dementia |
| DOIs | |
| State | Accepted/In press - 2017 |
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Keywords
- Alzheimer's disease
- Atherosclerosis Risk in Communities (ARIC) Study
- Dementia
- Mild cognitive impairment
- Obstructive sleep apnea
- Sleep duration
- Sleep Heart Health Study (SHHS)
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Geriatrics and Gerontology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
Cite this
Sleep characteristics and risk of dementia and Alzheimer's disease : The Atherosclerosis Risk in Communities Study. / Lutsey, Pamela L.; Misialek, Jeffrey R.; Mosley, Thomas H.; Gottesman, Rebecca F.; Punjabi, Naresh M.; Shahar, Eyal; MacLehose, Richard; Ogilvie, Rachel P.; Knopman, David; Alonso, Alvaro.
In: Alzheimer's and Dementia, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sleep characteristics and risk of dementia and Alzheimer's disease
T2 - The Atherosclerosis Risk in Communities Study
AU - Lutsey, Pamela L.
AU - Misialek, Jeffrey R.
AU - Mosley, Thomas H.
AU - Gottesman, Rebecca F.
AU - Punjabi, Naresh M.
AU - Shahar, Eyal
AU - MacLehose, Richard
AU - Ogilvie, Rachel P.
AU - Knopman, David
AU - Alonso, Alvaro
PY - 2017
Y1 - 2017
N2 - Introduction: This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia over 15 years of follow-up. Methods: A total of 1667 Atherosclerosis Risk in Communities Study participants underwent in-home polysomnography (1996-1998) and were followed for dementia. Dementia was defined by (1) hospitalization diagnosis codes (1996-2012) and (2) a comprehensive neurocognitive examination (2011-2013) with adjudication. Results: OSA and sleep duration were not associated with risk of incident dementia. When using adjudicated outcomes, severe OSA (≥30 vs. <5 apnea-hypopnea events/hour) was associated with higher risk of all-cause dementia (risk ratio [95% confidence interval], 2.35 [1.06-5.18]) and Alzheimer's disease dementia (1.66 [1.03-2.68]); associations were attenuated with cardiovascular risk factor adjustment. Sleeping <7 versus 8 to ≤9 hours was associated with higher risk of all-cause dementia (2.00 [1.03-3.86]). Discussion: When adjudicated outcome definitions were used, late-midlife OSA and short sleep duration were associated with all-cause and Alzheimer's disease dementia in later life.
AB - Introduction: This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia over 15 years of follow-up. Methods: A total of 1667 Atherosclerosis Risk in Communities Study participants underwent in-home polysomnography (1996-1998) and were followed for dementia. Dementia was defined by (1) hospitalization diagnosis codes (1996-2012) and (2) a comprehensive neurocognitive examination (2011-2013) with adjudication. Results: OSA and sleep duration were not associated with risk of incident dementia. When using adjudicated outcomes, severe OSA (≥30 vs. <5 apnea-hypopnea events/hour) was associated with higher risk of all-cause dementia (risk ratio [95% confidence interval], 2.35 [1.06-5.18]) and Alzheimer's disease dementia (1.66 [1.03-2.68]); associations were attenuated with cardiovascular risk factor adjustment. Sleeping <7 versus 8 to ≤9 hours was associated with higher risk of all-cause dementia (2.00 [1.03-3.86]). Discussion: When adjudicated outcome definitions were used, late-midlife OSA and short sleep duration were associated with all-cause and Alzheimer's disease dementia in later life.
KW - Alzheimer's disease
KW - Atherosclerosis Risk in Communities (ARIC) Study
KW - Dementia
KW - Mild cognitive impairment
KW - Obstructive sleep apnea
KW - Sleep duration
KW - Sleep Heart Health Study (SHHS)
UR - http://www.scopus.com/inward/record.url?scp=85028602281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028602281&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2017.06.2269
DO - 10.1016/j.jalz.2017.06.2269
M3 - Article
C2 - 28738188
AN - SCOPUS:85028602281
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
ER -