Sleep disorders in chronic obstructive pulmonary disease: Etiology, impact, and management

Rohit Budhiraja, Tauseef A. Siddiqi, Stuart F Quan

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality and may frequently be complicated by sleep disorders. Insomnia and obstructive sleep apnea are commonly encountered in patients with COPD. Nocturnal hypoxemia is also prevalent in COPD may occur despite adequate awake oxygenation and can be especially severe in rapid eye movement sleep. Additionally, several factors-some of them unique to COPD-can contribute to sleep-related hypoventilation. Recognition of hypoventilation can be vital as supplemental oxygen therapy itself can acutely worsen hypoventilation and lead to disastrous consequences. Finally, accruing data establish an association between restless leg syndrome and COPD-an association that may be driven by hypoxemia and/or hypercapnia. Comorbid sleep disorders portend worse sleep quality, diminished quality of life, and multifarious other adverse consequences. The awareness and knowledge regarding sleep comorbidities in COPD has continued to evolve over past many years. There are still several lacunae, however, in our understanding of the etiologies, impact, and therapies of sleep disorders, specifi cally in patients with COPD. This review summarizes the latest concepts in prevalence, pathogenesis, diagnosis, and management of diverse sleep disorders in COPD.

Original languageEnglish (US)
Pages (from-to)259-270
Number of pages12
JournalJournal of Clinical Sleep Medicine
Volume11
Issue number3
DOIs
StatePublished - 2015

Fingerprint

Chronic Obstructive Pulmonary Disease
Hypoventilation
Sleep
Restless Legs Syndrome
Hypercapnia
Sleep Wake Disorders
REM Sleep
Sleep Initiation and Maintenance Disorders
Obstructive Sleep Apnea
Comorbidity
Quality of Life
Oxygen
Morbidity
Mortality
Therapeutics

Keywords

  • COPD
  • Hypoventilation
  • Insomnia
  • Obstructive sleep apnea
  • Restless legs syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

Sleep disorders in chronic obstructive pulmonary disease : Etiology, impact, and management. / Budhiraja, Rohit; Siddiqi, Tauseef A.; Quan, Stuart F.

In: Journal of Clinical Sleep Medicine, Vol. 11, No. 3, 2015, p. 259-270.

Research output: Contribution to journalArticle

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