Sleep disturbance is associated with cardiovascular and metabolic disorders

Michael A. Grandner, Nicholas J. Jackson, Victoria M. Pak, Philip R. Gehrman

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Existing research has demonstrated associations between sleep duration and obesity, diabetes, cardiovascular disease and mortality. Sleep disorders research has shown that sleep apnoea, insomnia and other sleep disorders confer risk for cardiometabolic disease, particularly in the presence of reduced sleep duration. The aim of the present study was to examine the associations between general sleep disturbance, operationalized as 'difficulty falling asleep, staying asleep, or sleeping too much' as measured in a large, nationally representative sample, and self-reported history of myocardial infarction, stroke, coronary artery disease, diabetes and obesity. Data from the Behavioral Risk Factor Surveillance System were analysed. Complete data were available for 138201 individuals. A hierarchical logistic regression analysis examined associations before and after adjustment for demographic, socioeconomic, medical and psychological factors. After adjusting for demographic, socioeconomic and health risk factors, sleep duration was associated with obesity [odds ratio (OR)=1.18, P<0.0005), diabetes (OR=1.18, P<0.005), myocardial infarction (OR=1.36, P<0.0005), stroke (OR=1.22, P<0.05) and coronary artery disease (OR=1.59, P<0.0005). In fully adjusted models that included physical health, significant relationships remained for obesity (OR=1.14, P<0.0005), myocardial infarction (OR=1.23, P<0.005) and coronary artery disease (OR=1.43, P<0.0005). Sleep disturbance is a significant risk factor for obesity, diabetes, myocardial infarction, stroke and coronary artery disease, and effects for obesity, myocardial infarction and coronary artery disease are the most robust after adjustment. This study demonstrates that sleep disturbance is a novel risk factor that is potentially modifiable. Future research should determine whether sleep intervention could reduce the cardiometabolic consequences of sleep disturbance.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalJournal of Sleep Research
Volume21
Issue number4
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Sleep
Odds Ratio
Obesity
Coronary Artery Disease
Myocardial Infarction
Stroke
Demography
Behavioral Risk Factor Surveillance System
Social Adjustment
Sleep Apnea Syndromes
Health
Sleep Initiation and Maintenance Disorders
Research
Cardiovascular Diseases
Logistic Models
Regression Analysis
Psychology
Mortality

Keywords

  • Cardiovascular disease
  • Diabetes
  • Myocardial infarction
  • Obesity
  • Sleep
  • Stroke

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Sleep disturbance is associated with cardiovascular and metabolic disorders. / Grandner, Michael A.; Jackson, Nicholas J.; Pak, Victoria M.; Gehrman, Philip R.

In: Journal of Sleep Research, Vol. 21, No. 4, 01.08.2012, p. 427-433.

Research output: Contribution to journalArticle

Grandner, Michael A. ; Jackson, Nicholas J. ; Pak, Victoria M. ; Gehrman, Philip R. / Sleep disturbance is associated with cardiovascular and metabolic disorders. In: Journal of Sleep Research. 2012 ; Vol. 21, No. 4. pp. 427-433.
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