Sleep duration, cardiovascular disease, and proinflammatory biomarkers

Michael A. Grandner, Megan R. Sands-Lincoln, Victoria M. Pak, Sheila N. Garland

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations

Abstract

Habitual sleep duration has been associated with cardiometabolic disease, via several mechanistic pathways, but few have been thoroughly explored. One hypothesis is that short and/or long sleep duration is associated with a proinflammatory state, which could increase risk for cardiovascular and metabolic diseases. This hypothesis has been largely explored in the context of experimental sleep deprivation studies which have attempted to demonstrate changes in proinflammatory markers following acute sleep loss in the laboratory. Despite the controlled environment available in these studies, samples tend to lack general-ization to the population at large and acute sleep deprivation may not be a perfect analog for short sleep. To address these limitations, population based studies have explored associations between proinflammatory markers and habitual sleep duration. This review summarizes what is known from experimental and cross-sectional studies about the association between sleep duration, cardiovascular disease, and proinflammatory biomarkers. First, the association between sleep duration with both morbidity and mortality, with a focus on cardiovascular disease, is reviewed. Then, a brief review of the potential role of proinflammatory markers in cardiovascular disease is presented. The majority of this review details specific findings related to specific molecules, including tumor necrosis factor-α, interleukins-1,-6, and-17, C-reactive protein, coagulation molecules, cellular adhesion molecules, and visfatin. Finally, a discussion of the limitations of current studies and future directions is provided.

Original languageEnglish (US)
Pages (from-to)93-107
Number of pages15
JournalNature and Science of Sleep
Volume5
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Cytokines
  • Inflammation
  • Sleep duration

ASJC Scopus subject areas

  • Applied Psychology
  • Behavioral Neuroscience

Fingerprint

Dive into the research topics of 'Sleep duration, cardiovascular disease, and proinflammatory biomarkers'. Together they form a unique fingerprint.

Cite this