Sleep, glucose, and daytime functioning in youth with type 1 diabetes

Michelle M Perfect, Priti G. Patel, Roxanne E. Scott, Mark D Wheeler, Chetanbabu Patel, Kurt Griffin, Seth T. Sorensen, James L. Goodwin, Stuart F Quan

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Study Hypotheses: 1) Youth with evidence of SDB (total apnea-hypopnea index [Total-AHI] ≥ 1.5) would have significantly worse glucose control than those without SDB; 2) Elevated self-reported sleepiness in youth with T1DM would be related to compromised psychosocial functioning; and 3) Youth with T1DM would have significantly less slow wave sleep (SWS) than controls. Design: The study utilized home-based polysomnography, actigraphy, and questionnaires to assess sleep, and continuous glucose monitors and hemoglobin A1C (HbA1C) values to assess glucose control in youth with T1DM. We compared sleep of youth with T1DM to sleep of a matched control sample. Setting: Diabetic participants were recruited in a pediatric endocrinology clinic. Participants: Participants were youth (10 through 16 years) with T1DM. Controls, matched for sex, age, and BMI percentile, were from the Tucson Children's Assessment of Sleep Apnea study. Results: Participants with a Total-AHI ≥ 1.5 had higher glucose levels. Sleepiness and/or poor sleep habits correlated with reduced quality of life, depressed mood, lower grades, and lower state standardized reading scores. Diabetic youth spent more time (%) in stage N2 and less time in stage N3. Findings related to sleep architecture included associations between reduced SWS and higher HbA1C, worse quality of life, and sleepiness. More time (%) spent in stage N2 related to higher glucose levels/hyperglycemia, behavioral difficulties, reduced quality of life, lower grades, depression, sleep-wake behavior problems, poor sleep quality, sleepiness, and lower state standardized math scores. Conclusions: Sleep should be routinely assessed as part of diabetes management in youth with T1DM.

Original languageEnglish (US)
Pages (from-to)81-88
Number of pages8
JournalSleep
Volume35
Issue number1
DOIs
StatePublished - 2012

Fingerprint

Type 1 Diabetes Mellitus
Sleep
Glucose
Quality of Life
Apnea
Hemoglobins
Actigraphy
Polysomnography
Endocrinology
Sleep Apnea Syndromes
Hyperglycemia
Habits
Reading
Depression
Pediatrics

Keywords

  • Continuous glucose monitor
  • Polysomnography
  • Sleep
  • Type 1 diabetes
  • Youth

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Sleep, glucose, and daytime functioning in youth with type 1 diabetes. / Perfect, Michelle M; Patel, Priti G.; Scott, Roxanne E.; Wheeler, Mark D; Patel, Chetanbabu; Griffin, Kurt; Sorensen, Seth T.; Goodwin, James L.; Quan, Stuart F.

In: Sleep, Vol. 35, No. 1, 2012, p. 81-88.

Research output: Contribution to journalArticle

Perfect, MM, Patel, PG, Scott, RE, Wheeler, MD, Patel, C, Griffin, K, Sorensen, ST, Goodwin, JL & Quan, SF 2012, 'Sleep, glucose, and daytime functioning in youth with type 1 diabetes', Sleep, vol. 35, no. 1, pp. 81-88. https://doi.org/10.5665/sleep.1590
Perfect, Michelle M ; Patel, Priti G. ; Scott, Roxanne E. ; Wheeler, Mark D ; Patel, Chetanbabu ; Griffin, Kurt ; Sorensen, Seth T. ; Goodwin, James L. ; Quan, Stuart F. / Sleep, glucose, and daytime functioning in youth with type 1 diabetes. In: Sleep. 2012 ; Vol. 35, No. 1. pp. 81-88.
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abstract = "Study Hypotheses: 1) Youth with evidence of SDB (total apnea-hypopnea index [Total-AHI] ≥ 1.5) would have significantly worse glucose control than those without SDB; 2) Elevated self-reported sleepiness in youth with T1DM would be related to compromised psychosocial functioning; and 3) Youth with T1DM would have significantly less slow wave sleep (SWS) than controls. Design: The study utilized home-based polysomnography, actigraphy, and questionnaires to assess sleep, and continuous glucose monitors and hemoglobin A1C (HbA1C) values to assess glucose control in youth with T1DM. We compared sleep of youth with T1DM to sleep of a matched control sample. Setting: Diabetic participants were recruited in a pediatric endocrinology clinic. Participants: Participants were youth (10 through 16 years) with T1DM. Controls, matched for sex, age, and BMI percentile, were from the Tucson Children's Assessment of Sleep Apnea study. Results: Participants with a Total-AHI ≥ 1.5 had higher glucose levels. Sleepiness and/or poor sleep habits correlated with reduced quality of life, depressed mood, lower grades, and lower state standardized reading scores. Diabetic youth spent more time ({\%}) in stage N2 and less time in stage N3. Findings related to sleep architecture included associations between reduced SWS and higher HbA1C, worse quality of life, and sleepiness. More time ({\%}) spent in stage N2 related to higher glucose levels/hyperglycemia, behavioral difficulties, reduced quality of life, lower grades, depression, sleep-wake behavior problems, poor sleep quality, sleepiness, and lower state standardized math scores. Conclusions: Sleep should be routinely assessed as part of diabetes management in youth with T1DM.",
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AU - Perfect, Michelle M

AU - Patel, Priti G.

AU - Scott, Roxanne E.

AU - Wheeler, Mark D

AU - Patel, Chetanbabu

AU - Griffin, Kurt

AU - Sorensen, Seth T.

AU - Goodwin, James L.

AU - Quan, Stuart F

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AB - Study Hypotheses: 1) Youth with evidence of SDB (total apnea-hypopnea index [Total-AHI] ≥ 1.5) would have significantly worse glucose control than those without SDB; 2) Elevated self-reported sleepiness in youth with T1DM would be related to compromised psychosocial functioning; and 3) Youth with T1DM would have significantly less slow wave sleep (SWS) than controls. Design: The study utilized home-based polysomnography, actigraphy, and questionnaires to assess sleep, and continuous glucose monitors and hemoglobin A1C (HbA1C) values to assess glucose control in youth with T1DM. We compared sleep of youth with T1DM to sleep of a matched control sample. Setting: Diabetic participants were recruited in a pediatric endocrinology clinic. Participants: Participants were youth (10 through 16 years) with T1DM. Controls, matched for sex, age, and BMI percentile, were from the Tucson Children's Assessment of Sleep Apnea study. Results: Participants with a Total-AHI ≥ 1.5 had higher glucose levels. Sleepiness and/or poor sleep habits correlated with reduced quality of life, depressed mood, lower grades, and lower state standardized reading scores. Diabetic youth spent more time (%) in stage N2 and less time in stage N3. Findings related to sleep architecture included associations between reduced SWS and higher HbA1C, worse quality of life, and sleepiness. More time (%) spent in stage N2 related to higher glucose levels/hyperglycemia, behavioral difficulties, reduced quality of life, lower grades, depression, sleep-wake behavior problems, poor sleep quality, sleepiness, and lower state standardized math scores. Conclusions: Sleep should be routinely assessed as part of diabetes management in youth with T1DM.

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KW - Type 1 diabetes

KW - Youth

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