Slow conformational motions that favor sub-picosecond motions important for catalysis

J. R.Exequiel T. Pineda, Dimitri Antoniou, Steven D. Schwartz

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

It has been accepted for many years that functionally important motions are crucial to binding properties of ligands in such molecules as hemoglobin and myoglobin. In enzymatic reactions, theory and now experiment are beginning to confirm the importance of motions on a fast (ps) time scale in the chemical step of the catalytic process. What is missing is a clear physical picture of how slow conformational fluctuations are related to the fast motions that have been identified as crucial. This paper presents a theoretical analysis of this issue for human heart lactate dehydrogenase. We will examine how slow conformational motions bring the system to conformations that are distinguished as catalytically competent because they favor specific fast motions.

Original languageEnglish (US)
Pages (from-to)15985-15990
Number of pages6
JournalJournal of Physical Chemistry B
Volume114
Issue number48
DOIs
StatePublished - Dec 9 2010
Externally publishedYes

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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