Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Jin H. Song, Hyun Jin Kang, Libia A. Luevano, Vijay Gokhale, Kui Wu, Ritu Pandey, Hsiao-Hui Chow, Laurence Hurley, Andrew Kraft

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Small-molecule targeting of the cooperative folding process in the hTERT G-quadruplex promoter element produces telomerase-independent events, which impair mitochondrial processes resulting in apoptotic cell death and inhibition of prostate cancer cell growth.

Original languageEnglish (US)
Pages (from-to)1110-1121.e4
JournalCell Chemical Biology
Volume26
Issue number8
DOIs
StatePublished - Aug 15 2019

Fingerprint

G-Quadruplexes
Telomerase
Cell growth
Cell death
Prostatic Neoplasms
Cell Death
Molecules
Growth
Neoplasms

Keywords

  • docetaxel resistance
  • G-quadruplex
  • hTERT
  • NRF2
  • oxidative stress
  • prostate cancer
  • ROS
  • telomerase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death. / Song, Jin H.; Kang, Hyun Jin; Luevano, Libia A.; Gokhale, Vijay; Wu, Kui; Pandey, Ritu; Chow, Hsiao-Hui; Hurley, Laurence; Kraft, Andrew.

In: Cell Chemical Biology, Vol. 26, No. 8, 15.08.2019, p. 1110-1121.e4.

Research output: Contribution to journalArticle

Song, Jin H. ; Kang, Hyun Jin ; Luevano, Libia A. ; Gokhale, Vijay ; Wu, Kui ; Pandey, Ritu ; Chow, Hsiao-Hui ; Hurley, Laurence ; Kraft, Andrew. / Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death. In: Cell Chemical Biology. 2019 ; Vol. 26, No. 8. pp. 1110-1121.e4.
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AU - Wu, Kui

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AU - Chow, Hsiao-Hui

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