Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Jin H. Song, Hyun Jin Kang, Libia A. Luevano, Vijay Gokhale, Kui Wu, Ritu Pandey, Hsiao-Hui Chow, Laurence Hurley, Andrew Kraft

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Small-molecule targeting of the cooperative folding process in the hTERT G-quadruplex promoter element produces telomerase-independent events, which impair mitochondrial processes resulting in apoptotic cell death and inhibition of prostate cancer cell growth.

Original languageEnglish (US)
Pages (from-to)1110-1121.e4
JournalCell Chemical Biology
Volume26
Issue number8
DOIs
StatePublished - Aug 15 2019

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Keywords

  • docetaxel resistance
  • G-quadruplex
  • hTERT
  • NRF2
  • oxidative stress
  • prostate cancer
  • ROS
  • telomerase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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