Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death

Jin H. Song, Hyun Jin Kang, Libia A. Luevano, Vijay Gokhale, Kui Wu, Ritu Pandey, H. H. Sherry Chow, Laurence H. Hurley, Andrew S. Kraft

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Small-molecule targeting of the cooperative folding process in the hTERT G-quadruplex promoter element produces telomerase-independent events, which impair mitochondrial processes resulting in apoptotic cell death and inhibition of prostate cancer cell growth.

Original languageEnglish (US)
Pages (from-to)1110-1121.e4
JournalCell Chemical Biology
Volume26
Issue number8
DOIs
StatePublished - Aug 15 2019

Keywords

  • G-quadruplex
  • NRF2
  • ROS
  • docetaxel resistance
  • hTERT
  • oxidative stress
  • prostate cancer
  • telomerase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death'. Together they form a unique fingerprint.

Cite this