Smaller cornu ammonis 23/dentate gyrus volumes and elevated cortisol in multiple sclerosis patients with depressive symptoms

Stefan M. Gold, Kyle C. Kern, Mary-Frances O'Connor, Michael J. Montag, Aileen Kim, Ye S. Yoo, Barbara S. Giesser, Nancy L. Sicotte

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Background: The hippocampus is likely involved in mood disorders, but in vivo evidence for the role of anatomically distinct hippocampal subregions is lacking. Multiple sclerosis, an inflammatory disease of the central nervous system, is linked to a high prevalence of depression as well as hippocampal damage and may thus provide important insight into the pathologic correlates of medical depression. We examined the role of subregional hippocampal volume for depression in relapsing-remitting multiple sclerosis. Methods: Anatomically defined hippocampal subregional volumes (cornu ammonis 13 [CA1CA3] and the dentate gyrus [CA23DG], subiculum, entorhinal cortex) were measured using a high-resolution T2-weighted magnetic resonance imaging sequence in 29 relapsing-remitting multiple sclerosis patients and 20 matched healthy control subjects. Diurnal salivary cortisol was assessed at awakening, 4 pm, and 9 pm on 2 consecutive days. Subjects also completed the Beck Depression Inventory. Results: Multiple sclerosis patients showed smaller hippocampal volumes compared with control subjects, particularly in the CA1 and subiculum subregions. In addition, multiple sclerosis patients with depressive symptoms (Beck Depression Inventory score >13) also showed smaller CA23DG volumes and higher cortisol levels. Within the multiple sclerosis group, CA23DG volume was correlated with depressive symptoms and cortisol levels. There were no associations with number of previous steroid treatments, global atrophy, or disease duration. Conclusions: This report provides in vivo evidence for selective association of smaller CA23DG subregional volumes in the hippocampus with cortisol hypersecretion and depressive symptoms in multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)553-559
Number of pages7
JournalBiological Psychiatry
Volume68
Issue number6
DOIs
StatePublished - Sep 15 2010
Externally publishedYes

Fingerprint

Dentate Gyrus
Multiple Sclerosis
Hydrocortisone
Hippocampus
Depression
Relapsing-Remitting Multiple Sclerosis
Equipment and Supplies
Entorhinal Cortex
Central Nervous System Diseases
Mood Disorders
Atrophy
Healthy Volunteers
Steroids
Magnetic Resonance Imaging

Keywords

  • Cornu ammonis
  • cortisol
  • depression
  • hippocampus
  • neurodegeneration
  • relapsing-remitting multiple sclerosis

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Smaller cornu ammonis 23/dentate gyrus volumes and elevated cortisol in multiple sclerosis patients with depressive symptoms. / Gold, Stefan M.; Kern, Kyle C.; O'Connor, Mary-Frances; Montag, Michael J.; Kim, Aileen; Yoo, Ye S.; Giesser, Barbara S.; Sicotte, Nancy L.

In: Biological Psychiatry, Vol. 68, No. 6, 15.09.2010, p. 553-559.

Research output: Contribution to journalArticle

Gold, Stefan M. ; Kern, Kyle C. ; O'Connor, Mary-Frances ; Montag, Michael J. ; Kim, Aileen ; Yoo, Ye S. ; Giesser, Barbara S. ; Sicotte, Nancy L. / Smaller cornu ammonis 23/dentate gyrus volumes and elevated cortisol in multiple sclerosis patients with depressive symptoms. In: Biological Psychiatry. 2010 ; Vol. 68, No. 6. pp. 553-559.
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AU - Kern, Kyle C.

AU - O'Connor, Mary-Frances

AU - Montag, Michael J.

AU - Kim, Aileen

AU - Yoo, Ye S.

AU - Giesser, Barbara S.

AU - Sicotte, Nancy L.

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N2 - Background: The hippocampus is likely involved in mood disorders, but in vivo evidence for the role of anatomically distinct hippocampal subregions is lacking. Multiple sclerosis, an inflammatory disease of the central nervous system, is linked to a high prevalence of depression as well as hippocampal damage and may thus provide important insight into the pathologic correlates of medical depression. We examined the role of subregional hippocampal volume for depression in relapsing-remitting multiple sclerosis. Methods: Anatomically defined hippocampal subregional volumes (cornu ammonis 13 [CA1CA3] and the dentate gyrus [CA23DG], subiculum, entorhinal cortex) were measured using a high-resolution T2-weighted magnetic resonance imaging sequence in 29 relapsing-remitting multiple sclerosis patients and 20 matched healthy control subjects. Diurnal salivary cortisol was assessed at awakening, 4 pm, and 9 pm on 2 consecutive days. Subjects also completed the Beck Depression Inventory. Results: Multiple sclerosis patients showed smaller hippocampal volumes compared with control subjects, particularly in the CA1 and subiculum subregions. In addition, multiple sclerosis patients with depressive symptoms (Beck Depression Inventory score >13) also showed smaller CA23DG volumes and higher cortisol levels. Within the multiple sclerosis group, CA23DG volume was correlated with depressive symptoms and cortisol levels. There were no associations with number of previous steroid treatments, global atrophy, or disease duration. Conclusions: This report provides in vivo evidence for selective association of smaller CA23DG subregional volumes in the hippocampus with cortisol hypersecretion and depressive symptoms in multiple sclerosis.

AB - Background: The hippocampus is likely involved in mood disorders, but in vivo evidence for the role of anatomically distinct hippocampal subregions is lacking. Multiple sclerosis, an inflammatory disease of the central nervous system, is linked to a high prevalence of depression as well as hippocampal damage and may thus provide important insight into the pathologic correlates of medical depression. We examined the role of subregional hippocampal volume for depression in relapsing-remitting multiple sclerosis. Methods: Anatomically defined hippocampal subregional volumes (cornu ammonis 13 [CA1CA3] and the dentate gyrus [CA23DG], subiculum, entorhinal cortex) were measured using a high-resolution T2-weighted magnetic resonance imaging sequence in 29 relapsing-remitting multiple sclerosis patients and 20 matched healthy control subjects. Diurnal salivary cortisol was assessed at awakening, 4 pm, and 9 pm on 2 consecutive days. Subjects also completed the Beck Depression Inventory. Results: Multiple sclerosis patients showed smaller hippocampal volumes compared with control subjects, particularly in the CA1 and subiculum subregions. In addition, multiple sclerosis patients with depressive symptoms (Beck Depression Inventory score >13) also showed smaller CA23DG volumes and higher cortisol levels. Within the multiple sclerosis group, CA23DG volume was correlated with depressive symptoms and cortisol levels. There were no associations with number of previous steroid treatments, global atrophy, or disease duration. Conclusions: This report provides in vivo evidence for selective association of smaller CA23DG subregional volumes in the hippocampus with cortisol hypersecretion and depressive symptoms in multiple sclerosis.

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