Smartphone-based epifluorescence microscope for fresh tissue imaging

Wenbin Zhu, Giacomo Pirovano, Cheng Gong, Nachiket Kulkarni, Christopher David Nguyen, Christian Brand, Thomas Reiner, Dongkyun Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed a smartphone-based epifluorescence microscope for fresh tissue imaging. The smartphone microscope optics was optimally designed to achieve similar resolution (0.56 µm) and FOV (520 µm) as the bench 40x microscope, commonly used during the histopathologic analysis. Preliminary images obtained from an excised human pancreatic tissue stained with a rapid staining fluorescence dye (PARPi-FL) clearly visualized individual tumor cells.

Original languageEnglish (US)
Title of host publicationEuropean Conference on Biomedical Optics, ECBO_2019
PublisherOSA - The Optical Society
ISBN (Electronic)9781557528209
DOIs
StatePublished - Jan 1 2019
EventEuropean Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands
Duration: Jun 23 2019Jun 25 2019

Publication series

NameOptics InfoBase Conference Papers
VolumePart F142-ECBO 2019

Conference

ConferenceEuropean Conference on Biomedical Optics, ECBO_2019
CountryNetherlands
CityMunich
Period6/23/196/25/19

Keywords

  • Fluorescence microscopy
  • Fresh tissue imaging
  • Point-of-care
  • Smartphone microscope

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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  • Cite this

    Zhu, W., Pirovano, G., Gong, C., Kulkarni, N., Nguyen, C. D., Brand, C., Reiner, T., & Kang, D. (2019). Smartphone-based epifluorescence microscope for fresh tissue imaging. In European Conference on Biomedical Optics, ECBO_2019 (Optics InfoBase Conference Papers; Vol. Part F142-ECBO 2019). OSA - The Optical Society. https://doi.org/10.1117/12.2526857