Socio-demographic determinants of aflatoxin B1-lysine adduct levels among pregnant women in Kumasi, Ghana.

F. M. Shuaib, P. E. Jolly, John E Ehiri, W. O. Ellis, N. J. Yatich, E. Funkhouser, S. D. Person, J. H. Williams, G. Qian, J. S. Wang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Although studies have linked these toxins to adverse birth outcomes and poor infant development, no study has investigated the socio-demographic and economic determinants of aflatoxin levels among pregnant women living in sub-Saharan Africa. A cross-sectional study was conducted among 785 pregnant women in Kumasi. Aflatoxin B1 lysine adduct levels (AF-ALB) were determined by High Performance Liquid Chromatography. Analysis of variance was used to determine mean log AF-ALB levels and significance of differences in these levels according to socio-demographic variables. Logistic regression was used to identify independent associations of socio-demographics with having AF-ALB levels (≥ 11.34 pg/mg; upper quartile). AF-ALB levels ranged from 0.44 pg/mg to 268.73 pg/mg albumin with a median level of 5.0 pg/mg. Bivariate analyses indicates that mean ln AF-ALB as well as the percent of women having high AF-ALB levels (≥ 11.34 pg/mg; upper quartile) were inversely associated with indices of higher socioeconomic status: higher education and income, being employed and having a flush toilet. Higher income, being employed, having one child (verses no children) and having a flush toilet (verses no toilet facilities) were each independently associated with a 30-40% reduced odds of high AF-ALB levels. Additional research is needed to investigate how socio-demographic and economic factors interact to influence aflatoxin ingestion by individuals in regions with high aflatoxin crop contamination. This knowledge can be used to formulate and implement policies that will reduce exposure of women and their unborn children to these toxins.

Original languageEnglish (US)
Pages (from-to)179-188
Number of pages10
JournalGhana Medical Journal
Volume46
Issue number4
StatePublished - Dec 2012
Externally publishedYes

Fingerprint

Ghana
Aflatoxins
Pregnant Women
Demography
Toilet Facilities
Economics
Africa South of the Sahara
Child Development
Social Class
Developing Countries
Albumins
Analysis of Variance
Cross-Sectional Studies
Eating
Logistic Models
High Pressure Liquid Chromatography
Parturition
Education
Food
aflatoxin B1-lysine adduct

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Shuaib, F. M., Jolly, P. E., Ehiri, J. E., Ellis, W. O., Yatich, N. J., Funkhouser, E., ... Wang, J. S. (2012). Socio-demographic determinants of aflatoxin B1-lysine adduct levels among pregnant women in Kumasi, Ghana. Ghana Medical Journal, 46(4), 179-188.

Socio-demographic determinants of aflatoxin B1-lysine adduct levels among pregnant women in Kumasi, Ghana. / Shuaib, F. M.; Jolly, P. E.; Ehiri, John E; Ellis, W. O.; Yatich, N. J.; Funkhouser, E.; Person, S. D.; Williams, J. H.; Qian, G.; Wang, J. S.

In: Ghana Medical Journal, Vol. 46, No. 4, 12.2012, p. 179-188.

Research output: Contribution to journalArticle

Shuaib, FM, Jolly, PE, Ehiri, JE, Ellis, WO, Yatich, NJ, Funkhouser, E, Person, SD, Williams, JH, Qian, G & Wang, JS 2012, 'Socio-demographic determinants of aflatoxin B1-lysine adduct levels among pregnant women in Kumasi, Ghana.', Ghana Medical Journal, vol. 46, no. 4, pp. 179-188.
Shuaib, F. M. ; Jolly, P. E. ; Ehiri, John E ; Ellis, W. O. ; Yatich, N. J. ; Funkhouser, E. ; Person, S. D. ; Williams, J. H. ; Qian, G. ; Wang, J. S. / Socio-demographic determinants of aflatoxin B1-lysine adduct levels among pregnant women in Kumasi, Ghana. In: Ghana Medical Journal. 2012 ; Vol. 46, No. 4. pp. 179-188.
@article{e7e9774243fd48e59fd30249e3aef636,
title = "Socio-demographic determinants of aflatoxin B1-lysine adduct levels among pregnant women in Kumasi, Ghana.",
abstract = "Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Although studies have linked these toxins to adverse birth outcomes and poor infant development, no study has investigated the socio-demographic and economic determinants of aflatoxin levels among pregnant women living in sub-Saharan Africa. A cross-sectional study was conducted among 785 pregnant women in Kumasi. Aflatoxin B1 lysine adduct levels (AF-ALB) were determined by High Performance Liquid Chromatography. Analysis of variance was used to determine mean log AF-ALB levels and significance of differences in these levels according to socio-demographic variables. Logistic regression was used to identify independent associations of socio-demographics with having AF-ALB levels (≥ 11.34 pg/mg; upper quartile). AF-ALB levels ranged from 0.44 pg/mg to 268.73 pg/mg albumin with a median level of 5.0 pg/mg. Bivariate analyses indicates that mean ln AF-ALB as well as the percent of women having high AF-ALB levels (≥ 11.34 pg/mg; upper quartile) were inversely associated with indices of higher socioeconomic status: higher education and income, being employed and having a flush toilet. Higher income, being employed, having one child (verses no children) and having a flush toilet (verses no toilet facilities) were each independently associated with a 30-40{\%} reduced odds of high AF-ALB levels. Additional research is needed to investigate how socio-demographic and economic factors interact to influence aflatoxin ingestion by individuals in regions with high aflatoxin crop contamination. This knowledge can be used to formulate and implement policies that will reduce exposure of women and their unborn children to these toxins.",
author = "Shuaib, {F. M.} and Jolly, {P. E.} and Ehiri, {John E} and Ellis, {W. O.} and Yatich, {N. J.} and E. Funkhouser and Person, {S. D.} and Williams, {J. H.} and G. Qian and Wang, {J. S.}",
year = "2012",
month = "12",
language = "English (US)",
volume = "46",
pages = "179--188",
journal = "Ghana Medical Journal",
issn = "0016-9560",
publisher = "Ghana Medical Association",
number = "4",

}

TY - JOUR

T1 - Socio-demographic determinants of aflatoxin B1-lysine adduct levels among pregnant women in Kumasi, Ghana.

AU - Shuaib, F. M.

AU - Jolly, P. E.

AU - Ehiri, John E

AU - Ellis, W. O.

AU - Yatich, N. J.

AU - Funkhouser, E.

AU - Person, S. D.

AU - Williams, J. H.

AU - Qian, G.

AU - Wang, J. S.

PY - 2012/12

Y1 - 2012/12

N2 - Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Although studies have linked these toxins to adverse birth outcomes and poor infant development, no study has investigated the socio-demographic and economic determinants of aflatoxin levels among pregnant women living in sub-Saharan Africa. A cross-sectional study was conducted among 785 pregnant women in Kumasi. Aflatoxin B1 lysine adduct levels (AF-ALB) were determined by High Performance Liquid Chromatography. Analysis of variance was used to determine mean log AF-ALB levels and significance of differences in these levels according to socio-demographic variables. Logistic regression was used to identify independent associations of socio-demographics with having AF-ALB levels (≥ 11.34 pg/mg; upper quartile). AF-ALB levels ranged from 0.44 pg/mg to 268.73 pg/mg albumin with a median level of 5.0 pg/mg. Bivariate analyses indicates that mean ln AF-ALB as well as the percent of women having high AF-ALB levels (≥ 11.34 pg/mg; upper quartile) were inversely associated with indices of higher socioeconomic status: higher education and income, being employed and having a flush toilet. Higher income, being employed, having one child (verses no children) and having a flush toilet (verses no toilet facilities) were each independently associated with a 30-40% reduced odds of high AF-ALB levels. Additional research is needed to investigate how socio-demographic and economic factors interact to influence aflatoxin ingestion by individuals in regions with high aflatoxin crop contamination. This knowledge can be used to formulate and implement policies that will reduce exposure of women and their unborn children to these toxins.

AB - Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Although studies have linked these toxins to adverse birth outcomes and poor infant development, no study has investigated the socio-demographic and economic determinants of aflatoxin levels among pregnant women living in sub-Saharan Africa. A cross-sectional study was conducted among 785 pregnant women in Kumasi. Aflatoxin B1 lysine adduct levels (AF-ALB) were determined by High Performance Liquid Chromatography. Analysis of variance was used to determine mean log AF-ALB levels and significance of differences in these levels according to socio-demographic variables. Logistic regression was used to identify independent associations of socio-demographics with having AF-ALB levels (≥ 11.34 pg/mg; upper quartile). AF-ALB levels ranged from 0.44 pg/mg to 268.73 pg/mg albumin with a median level of 5.0 pg/mg. Bivariate analyses indicates that mean ln AF-ALB as well as the percent of women having high AF-ALB levels (≥ 11.34 pg/mg; upper quartile) were inversely associated with indices of higher socioeconomic status: higher education and income, being employed and having a flush toilet. Higher income, being employed, having one child (verses no children) and having a flush toilet (verses no toilet facilities) were each independently associated with a 30-40% reduced odds of high AF-ALB levels. Additional research is needed to investigate how socio-demographic and economic factors interact to influence aflatoxin ingestion by individuals in regions with high aflatoxin crop contamination. This knowledge can be used to formulate and implement policies that will reduce exposure of women and their unborn children to these toxins.

UR - http://www.scopus.com/inward/record.url?scp=84893505326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893505326&partnerID=8YFLogxK

M3 - Article

C2 - 23661836

AN - SCOPUS:84893505326

VL - 46

SP - 179

EP - 188

JO - Ghana Medical Journal

JF - Ghana Medical Journal

SN - 0016-9560

IS - 4

ER -