Solid-phase organic synthesis: Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions

Josef Vágner; Viktor Krchňák; Michal Lebl; George Barany

doi:10.1135/cccc19961697

Solid-phase organic synthesis: Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions

Josef Vágner, Viktor Krchňák, Michal Lebl, George Barany

BIO5, Institute of

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11 Scopus citations

Abstract

Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.

Original language	English (US)
Pages (from-to)	1697-1702
Number of pages	6
Journal	Collection of Czechoslovak Chemical Communications
Volume	61
Issue number	12
DOIs	https://doi.org/10.1135/cccc19961697
State	Published - Dec 1996

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Keywords

Combinatorial chemistry
Solid-phase synthesis
Wittig reaction

ASJC Scopus subject areas

Chemistry(all)

Cite this

Vágner, J., Krchňák, V., Lebl, M., & Barany, G. (1996). Solid-phase organic synthesis: Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions. Collection of Czechoslovak Chemical Communications, 61(12), 1697-1702. https://doi.org/10.1135/cccc19961697

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Access to Document

10.1135/cccc19961697