Solid-phase organic synthesis: Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions

Josef Vágner; Viktor Krchňák; Michal Lebl; George Barany

doi:10.1135/cccc19961697

Solid-phase organic synthesis: Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions

Josef Vágner, Viktor Krchňák, Michal Lebl, George Barany

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.

Original language	English (US)
Pages (from-to)	1697-1702
Number of pages	6
Journal	Collection of Czechoslovak Chemical Communications
Volume	61
Issue number	12
DOIs	https://doi.org/10.1135/cccc19961697
State	Published - Dec 1996
Externally published	Yes

Keywords

Combinatorial chemistry
Solid-phase synthesis
Wittig reaction

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1135/cccc19961697

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title = "Solid-phase organic synthesis: Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions",

abstract = "Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.",

keywords = "Combinatorial chemistry, Solid-phase synthesis, Wittig reaction",

author = "Josef V{\'a}gner and Viktor Krch{\v n}{\'a}k and Michal Lebl and George Barany",

year = "1996",

month = dec,

doi = "10.1135/cccc19961697",

language = "English (US)",

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pages = "1697--1702",

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T2 - Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions

AU - Vágner, Josef

AU - Krchňák, Viktor

AU - Lebl, Michal

AU - Barany, George

PY - 1996/12

Y1 - 1996/12

N2 - Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.

AB - Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.

KW - Combinatorial chemistry

KW - Solid-phase synthesis

KW - Wittig reaction

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