Solid-phase organic synthesis: Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions

Josef Vágner, Viktor Krchňák, Michal Lebl, George Barany

Research output: Contribution to journalArticle

11 Scopus citations


Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.

Original languageEnglish (US)
Pages (from-to)1697-1702
Number of pages6
JournalCollection of Czechoslovak Chemical Communications
Issue number12
StatePublished - Dec 1996



  • Combinatorial chemistry
  • Solid-phase synthesis
  • Wittig reaction

ASJC Scopus subject areas

  • Chemistry(all)

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