Abstract
Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1697-1702 |
| Number of pages | 6 |
| Journal | Collection of Czechoslovak Chemical Communications |
| Volume | 61 |
| Issue number | 12 |
| State | Published - Dec 1996 |
| Externally published | Yes |
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Keywords
- Combinatorial chemistry
- Solid-phase synthesis
- Wittig reaction
ASJC Scopus subject areas
- Chemistry(all)
Cite this
Solid-phase organic synthesis : Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions. / Vagner, Josef; Krchňák, Viktor; Lebl, Michal; Barany, George.
In: Collection of Czechoslovak Chemical Communications, Vol. 61, No. 12, 12.1996, p. 1697-1702.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Solid-phase organic synthesis
T2 - Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions
AU - Vagner, Josef
AU - Krchňák, Viktor
AU - Lebl, Michal
AU - Barany, George
PY - 1996/12
Y1 - 1996/12
N2 - Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.
AB - Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.
KW - Combinatorial chemistry
KW - Solid-phase synthesis
KW - Wittig reaction
UR - http://www.scopus.com/inward/record.url?scp=21444457679&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21444457679&partnerID=8YFLogxK
M3 - Article
VL - 61
SP - 1697
EP - 1702
JO - ChemPlusChem
JF - ChemPlusChem
SN - 2192-6506
IS - 12
ER -