Solid-phase organic synthesis: Creation of carbon-carbon double bonds under mild conditions by Wittig-type reactions

Josef Vágner, Viktor Krchňák, Michal Lebl, George Barany

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Phosphorane ylides and phosphonate anions react smoothly with resin-bound aldehydes and ketones to provide alkenes in good yields and purities (assessed after cleavage of acid-labile PAL anchor to support). The reactions of aldehydes give excellent stereoselectivities. Effective conditions have been developed for carrying out these transformations.

Original languageEnglish (US)
Pages (from-to)1697-1702
Number of pages6
JournalCollection of Czechoslovak Chemical Communications
Volume61
Issue number12
DOIs
StatePublished - Dec 1996
Externally publishedYes

Keywords

  • Combinatorial chemistry
  • Solid-phase synthesis
  • Wittig reaction

ASJC Scopus subject areas

  • Chemistry(all)

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