Solid tumor inhibitory and other constituents of Casimiroa tetrameria

Ya Ming Xu, Maria del C Ramirez-Ahumada, Frederick A. Valeriote, Leslie Gunatilaka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: To isolate and characterize solid tumor inhibitory and other constituents from a bioactive extract of Casimiroa tetrameria ((Rutaceae). Methods: A crude extract of C. tetrameria obtained from the US National Cancer Institute Natural Product Repository and found to exhibit selective toxicity to solid tumor cells was subjected bioactivity-guided fractionation involving solvent-solvent partitioning, gel filtration, and chromatography. The structures of all isolated compounds were elucidated by spectroscopic analysis (NMR and MS) and/or by comparison with the reported data. Compounds 1 and 4-9 were evaluated for their solid tumor selective cytotoxicity. Results: Nine metabolites, including a new furanocoumarin, 5-methoxy-8-(4'-acetoxy-3'-methylbut-2-enyloxy)-psoralen (1), and the previously known compounds 2-9 were encountered. Of these the flavonoid zapotin (6), and N-benzoyltyramide derivatives 7 and 8 were found to be the active constituents. Conclusion: Zapotin (6) is the most potent constituent of C. tetrameria with solid tumor selectivity.

Original languageEnglish (US)
Pages (from-to)334-337
Number of pages4
JournalChinese Journal of Natural Medicines
Volume9
Issue number5
DOIs
StatePublished - Sep 2011

Fingerprint

Casimiroa
Neoplasms
Rutaceae
Ficusin
National Cancer Institute (U.S.)
Biological Products
Complex Mixtures
Flavonoids
Gel Chromatography

Keywords

  • Casimiroa tetrameria
  • Flavonoids
  • Furanocoumarins
  • N-benzoyltyramides
  • Rutaceae
  • Solid tumor selectivity
  • Zapotin

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Drug Discovery

Cite this

Solid tumor inhibitory and other constituents of Casimiroa tetrameria. / Xu, Ya Ming; Ramirez-Ahumada, Maria del C; Valeriote, Frederick A.; Gunatilaka, Leslie.

In: Chinese Journal of Natural Medicines, Vol. 9, No. 5, 09.2011, p. 334-337.

Research output: Contribution to journalArticle

Xu, Ya Ming ; Ramirez-Ahumada, Maria del C ; Valeriote, Frederick A. ; Gunatilaka, Leslie. / Solid tumor inhibitory and other constituents of Casimiroa tetrameria. In: Chinese Journal of Natural Medicines. 2011 ; Vol. 9, No. 5. pp. 334-337.
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