Solid tumor inhibitory and other constituents of Casimiroa tetrameria

Ya Ming Xu, Maria del C. Ramirez-Ahumada, Frederick A. Valeriote, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Aim: To isolate and characterize solid tumor inhibitory and other constituents from a bioactive extract of Casimiroa tetrameria ((Rutaceae). Methods: A crude extract of C. tetrameria obtained from the US National Cancer Institute Natural Product Repository and found to exhibit selective toxicity to solid tumor cells was subjected bioactivity-guided fractionation involving solvent-solvent partitioning, gel filtration, and chromatography. The structures of all isolated compounds were elucidated by spectroscopic analysis (NMR and MS) and/or by comparison with the reported data. Compounds 1 and 4-9 were evaluated for their solid tumor selective cytotoxicity. Results: Nine metabolites, including a new furanocoumarin, 5-methoxy-8-(4'-acetoxy-3'-methylbut-2-enyloxy)-psoralen (1), and the previously known compounds 2-9 were encountered. Of these the flavonoid zapotin (6), and N-benzoyltyramide derivatives 7 and 8 were found to be the active constituents. Conclusion: Zapotin (6) is the most potent constituent of C. tetrameria with solid tumor selectivity.

Original languageEnglish (US)
Pages (from-to)334-337
Number of pages4
JournalChinese Journal of Natural Medicines
Volume9
Issue number5
DOIs
StatePublished - Sep 2011

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Keywords

  • Casimiroa tetrameria
  • Flavonoids
  • Furanocoumarins
  • N-benzoyltyramides
  • Rutaceae
  • Solid tumor selectivity
  • Zapotin

ASJC Scopus subject areas

  • Drug Discovery
  • Complementary and alternative medicine

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