Solubility and partitioning. VI: Octanol solubility and octanol-water partition coefficients

Samuel H Yalkowsky, S. C. Valvani, T. J. Roseman

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

A simple equation for the estimation of the aqueous solubility of crystalline solutes was previously derived based on the assumption that the presence of water does not significantly alter the crystal properties of the solute. The data presented verify the solubility equation for a set of 36 nonelectrolytes and weak electrolytes. Using the same set of solutes, the two major assumptions used to derive the equation were also verified: that the octanol solubility of nonelectrolytes is exponentially proportional to the melting point of the solute and that the octanol-water solubility ratio is a good approximation of the octanol-water partition coefficient.

Original languageEnglish (US)
Pages (from-to)866-870
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume72
Issue number8
StatePublished - 1983

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Octanols
Solubility
Water
Freezing
Electrolytes
Melting point
Crystalline materials
Crystals

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Solubility and partitioning. VI : Octanol solubility and octanol-water partition coefficients. / Yalkowsky, Samuel H; Valvani, S. C.; Roseman, T. J.

In: Journal of Pharmaceutical Sciences, Vol. 72, No. 8, 1983, p. 866-870.

Research output: Contribution to journalArticle

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