Solubility and partitioning VI: Octanol solubility and octanol–water partition coefficients

S. H. Yalkowsky, S. C. Valvani, T. J. Roseman

Research output: Contribution to journalArticle

173 Scopus citations

Abstract

A simple equation for the estimation of the aqueous solubility of crystalline solutes was previously derived based on the assumption that the presence of water does not significantly alter the crystal properties of the solute. The data presented verify the solubility equation for a set of 36 nonelectrolytes and weak electrolytes. Using the same set of solutes, the two major assumptions used to derive the equation were also verified: that the octanol solubility of nonelectrolytes is exponentially proportional to the melting point of the solute and that the octanol–water solubility ratio is a good approximation of the octanol–water partition coefficient.

Original languageEnglish (US)
Pages (from-to)866-870
Number of pages5
JournalJournal of pharmaceutical sciences
Volume72
Issue number8
DOIs
StatePublished - Aug 1983

Keywords

  • Octanol—determination of the solubility of nonelectrolytes and weak electrolytes, partition coefficients with water
  • Partition coefficient—of nonelectrolytes and weak electrolytes in octanol–water, use with melting point to determine solubility
  • Solubility—of nonelectrolytes and weak electrolytes in octanol, determination using melting points and partition coefficients

ASJC Scopus subject areas

  • Pharmaceutical Science

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