A simple equation for the estimation of the aqueous solubility of crystalline solutes was previously derived based on the assumption that the presence of water does not significantly alter the crystal properties of the solute. The data presented verify the solubility equation for a set of 36 nonelectrolytes and weak electrolytes. Using the same set of solutes, the two major assumptions used to derive the equation were also verified: that the octanol solubility of nonelectrolytes is exponentially proportional to the melting point of the solute and that the octanol–water solubility ratio is a good approximation of the octanol–water partition coefficient.
- Octanol—determination of the solubility of nonelectrolytes and weak electrolytes, partition coefficients with water
- Partition coefficient—of nonelectrolytes and weak electrolytes in octanol–water, use with melting point to determine solubility
- Solubility—of nonelectrolytes and weak electrolytes in octanol, determination using melting points and partition coefficients
ASJC Scopus subject areas
- Pharmaceutical Science