Solubility of nonelectrolytes in polar solvents II: Solubility of aliphatic alcohols in water

G. L. Amidon, S. H. Yalkowsky, S. Leung

Research output: Contribution to journalArticle

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The surface areas for 73 aliphatic hydrocarbons and alcohols, for which solubility and boiling point data are available, were calculated. The solubility of the alcohols and hydrocarbons can be quantitatively related to a combination of the hydrocarbon and hydroxyl surface areas of the molecules. The boiling points of the alcohols also correlated well with these two parameters. Isomeric alcohols, having a lower hydrocarbon surface area and/or a lower hydroxyl group surface area, are more soluble in water. The correlations show that branching, cyclization, and positional isomerism can be accounted for without introducing additional terms.

Original languageEnglish (US)
Pages (from-to)1858-1866
Number of pages9
JournalJournal of pharmaceutical sciences
Issue number12
StatePublished - Dec 1974
Externally publishedYes



  • Alcohols, aliphatic—solubility in water, correlated with surface areas and boiling points
  • Aliphatic hydrocarbons and alcohols—solubility of 73 determined, correlated with surface areas and boiling points
  • Solubility—73 aliphatic alcohols in water, correlated with surface areas and boiling points
  • Surface areas—73 aliphatic hydrocarbons and alcohols, correlated with solubility in water and boiling points

ASJC Scopus subject areas

  • Pharmaceutical Science

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