Abstract
The log-linear solubility equation, log (S(m)/S(w)) = fσ, where S(m) and S(w) are the solubilities of drug in the solvent mixture and water respectively, f is the volume fraction of cosolvent, and σ is the slope of the log (S(m)/S(w)) vs. f plot, has been applied to the solubilities of benzocaine, diazepam, and phenytoin in mixtures of polar, aprotic cosolvents, and water. These solvent systems were considered as two groups based on the functional group of the cosolvents; ethers (dioxane, dimethyl isosorbide, triglyme) and double-bonded oxygen compounds (DMSO, DMA, DMF). Solubilities are generally higher in both groups of cosolvent-water mixtures compared to amphiprotic cosolvent-water mixtures. This may be due to the lack of self-association of these cosolvents through hydrogen bonds and their relatively high-base strength. Positive and negative deviation from the predicted linear behavior occurs in these solvents systems as in the case of the amphiprotic cosolvent-water systems. Positive deviation is seen for all three solutes in the case of the ether cosolvent-water mixtures and for benzocaine and phenytoin in the double-bonded oxygen cosolvent-water mixtures. Negative deviations are seen for diazepam in the latter solvent system. The potential reasons for these deviations are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 172-176 |
| Number of pages | 5 |
| Journal | Journal of Parenteral Science and Technology |
| Volume | 41 |
| Issue number | 5 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Solubilization by cosolvents IV : Benzocaine, diazepam and phenytoin in aprotic cosolvent-water mixtures. / Rubino, J. T.; Blanchard, J.; Yalkowsky, Samuel H.
In: Journal of Parenteral Science and Technology, Vol. 41, No. 5, 1987, p. 172-176.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Solubilization by cosolvents IV
T2 - Benzocaine, diazepam and phenytoin in aprotic cosolvent-water mixtures
AU - Rubino, J. T.
AU - Blanchard, J.
AU - Yalkowsky, Samuel H
PY - 1987
Y1 - 1987
N2 - The log-linear solubility equation, log (S(m)/S(w)) = fσ, where S(m) and S(w) are the solubilities of drug in the solvent mixture and water respectively, f is the volume fraction of cosolvent, and σ is the slope of the log (S(m)/S(w)) vs. f plot, has been applied to the solubilities of benzocaine, diazepam, and phenytoin in mixtures of polar, aprotic cosolvents, and water. These solvent systems were considered as two groups based on the functional group of the cosolvents; ethers (dioxane, dimethyl isosorbide, triglyme) and double-bonded oxygen compounds (DMSO, DMA, DMF). Solubilities are generally higher in both groups of cosolvent-water mixtures compared to amphiprotic cosolvent-water mixtures. This may be due to the lack of self-association of these cosolvents through hydrogen bonds and their relatively high-base strength. Positive and negative deviation from the predicted linear behavior occurs in these solvents systems as in the case of the amphiprotic cosolvent-water systems. Positive deviation is seen for all three solutes in the case of the ether cosolvent-water mixtures and for benzocaine and phenytoin in the double-bonded oxygen cosolvent-water mixtures. Negative deviations are seen for diazepam in the latter solvent system. The potential reasons for these deviations are discussed.
AB - The log-linear solubility equation, log (S(m)/S(w)) = fσ, where S(m) and S(w) are the solubilities of drug in the solvent mixture and water respectively, f is the volume fraction of cosolvent, and σ is the slope of the log (S(m)/S(w)) vs. f plot, has been applied to the solubilities of benzocaine, diazepam, and phenytoin in mixtures of polar, aprotic cosolvents, and water. These solvent systems were considered as two groups based on the functional group of the cosolvents; ethers (dioxane, dimethyl isosorbide, triglyme) and double-bonded oxygen compounds (DMSO, DMA, DMF). Solubilities are generally higher in both groups of cosolvent-water mixtures compared to amphiprotic cosolvent-water mixtures. This may be due to the lack of self-association of these cosolvents through hydrogen bonds and their relatively high-base strength. Positive and negative deviation from the predicted linear behavior occurs in these solvents systems as in the case of the amphiprotic cosolvent-water systems. Positive deviation is seen for all three solutes in the case of the ether cosolvent-water mixtures and for benzocaine and phenytoin in the double-bonded oxygen cosolvent-water mixtures. Negative deviations are seen for diazepam in the latter solvent system. The potential reasons for these deviations are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0023614747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023614747&partnerID=8YFLogxK
M3 - Article
C2 - 3694340
AN - SCOPUS:0023614747
VL - 41
SP - 172
EP - 176
JO - PDA Journal of Pharmaceutical Science and Technology
JF - PDA Journal of Pharmaceutical Science and Technology
SN - 1079-7440
IS - 5
ER -