Solubilization of diazepam

F. A. Alvarez Núñez, S. H. Yalkowsky

Research output: Contribution to journalArticle

21 Scopus citations


Several attempts to increase diazepam solubility are in the literature. This study discusses these different solubilization approaches. Specific reference is given to the rationale in the application of pH control, cosolvency, surfactants, and cyclodextrins. It was found than cosolvency is a more attractive means of solubilizing diazepam than either pH control, surfactants, or cyclodextrins. Advantages, assumptions, and limitations of these diazepam solubilization techniques are also described.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalPDA Journal of Pharmaceutical Science and Technology
Issue number1
StatePublished - Jan 1 1998


ASJC Scopus subject areas

  • Pharmaceutical Science

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