Solubilization of fluasterone

Luwei Zhao, Ping Li, Samuel H. Yalkowsky

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Solubilization of nonpolar drugs constitutes one of the most important tasks in parenteral formulations design. This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation. Of the solubilizing agents used, the modified β-cyclodextrins were found to be the most effective. The solubility of Fluasterone is 1.55 x 10-4 mM, 3.13 mM, and 4.04 mM in water, 20% sulfobutyl ether-β-cyclodextrin (SBEβCD), and 20% hydroxypropyl-β- cyclodextrin (HPβCD), respectively.

Original languageEnglish (US)
Pages (from-to)967-969
Number of pages3
JournalJournal of pharmaceutical sciences
Volume88
Issue number10
DOIs
StatePublished - Oct 1999

ASJC Scopus subject areas

  • Pharmaceutical Science

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