Solubilization of rapamycin

Pahala Simamora, Joan M. Alvarez, Samuel H Yalkowsky

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (> 1000-fold) increase in the aqueous solubility of rapamycin.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume213
Issue number1-2
DOIs
StatePublished - Feb 1 2001

Fingerprint

Sirolimus
Water
Investigational Drugs
Benzyl Alcohol
Propylene Glycol
Benzoic Acid
Benzoates
Immunosuppressive Agents
Solubility
Ethanol

Keywords

  • Cosolvent
  • Hydrotrope
  • Hydrotropy
  • Rapamycin
  • Solubility
  • Solubilization

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Solubilization of rapamycin. / Simamora, Pahala; Alvarez, Joan M.; Yalkowsky, Samuel H.

In: International Journal of Pharmaceutics, Vol. 213, No. 1-2, 01.02.2001, p. 25-29.

Research output: Contribution to journalArticle

Simamora, Pahala ; Alvarez, Joan M. ; Yalkowsky, Samuel H. / Solubilization of rapamycin. In: International Journal of Pharmaceutics. 2001 ; Vol. 213, No. 1-2. pp. 25-29.
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