Solubilization of rapamycin

Pahala Simamora, Joan M. Alvarez, Samuel H. Yalkowsky

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (> 1000-fold) increase in the aqueous solubility of rapamycin.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume213
Issue number1-2
DOIs
StatePublished - Feb 1 2001

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Keywords

  • Cosolvent
  • Hydrotrope
  • Hydrotropy
  • Rapamycin
  • Solubility
  • Solubilization

ASJC Scopus subject areas

  • Pharmaceutical Science

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